ESCRS - PO829 - Comparison Of Corneal Tomographic And Biomechanical Parameters In Keratoconus, First Degree Relatives And Normal

Comparison Of Corneal Tomographic And Biomechanical Parameters In Keratoconus, First Degree Relatives And Normal

Published 2024 - 42nd Congress of the ESCRS

Reference: PO829 | Type: Free paper | DOI: 10.82333/1bgm-ev82

Authors: WAN HASLINA WAN ABDUL HALIM* 1 , NORSYARIZA RAZAK 1 , BARIAH MOHD ALI 2

1OPHTHALMOLOGY,NATIONAL UNIVERSITY OF MALAYSIA,KUALA LUMPUR,Malaysia, 2OPTOMETRY AND VISUAL SCIENCES,NATIONAL UNIVERSITY OF MALAYSIA,KUALA LUMPUR,Malaysia

Purpose

To compare the corneal tomography and corneal biomechanics parameters between Keratoconus (KCN) patients with their First-Degree Relatives (FDR) and normal

Setting

Hospital based population, single centre

Methods

A cross-sectional comparative study involving 78 Keratoconus subjects, 52 First Degree Relatives subjects, and 80 Normal subjects. Corneal tomography and corneal biomechanics was measured using Pentacam HR and Corvis ST (Oculus GmBh). Diagnosis of KCN was established clinically and by corneal topographic patterns.

Results

All corneal tomography and corneal biomechanics parameters were significantly different between the three groups (p<0.05). Corneal tomography parameters between FDR and normal showed differences in BAD_D, KISA, CCT, TP, and ARTmax with p<0.05. Corneal biomechanics parameters between FDR and normal are significantly different in CCT, SPA1, DA, A1V, A2V, A1T, HCPD, and HCDA (p<0.05). BAD_D and TBI showed the highest diagnostic ability of AUC (area under curve) to differentiate between normal cornea and ectasia.

Conclusions

BAD-D index from Pentacam and TBI index from Corvis ST were the potential screening parameters for detection of KC among FDR.