Clinical Application And Observation Of Cbi/Tbi Based On Racial Difference Correction On A Large Sample Of Chinese Han Eyes

Applying the modified CBl and TBI from the database of Chinese Han population and the original CBl and TBI diagnostic system,  completed the observation of clinical data of a large sample of Chinese Han population and explored the differences in specificity and sensitivity of clinical keratoconus screening.

Baiji ,Baiji Ophthalmology Hospital, Chongqing, China，400042

Using the modified CBl and TBI diagnostic system ( China-CBI，China-TBI ) of the Chinese Han population database and Global-CBl、Global-TBI diagnostic system, completed the examinations of normal eyes (830 eyes), keratoconus eyes (12 eyes), and forme fruste keratoconus eyes (8 eyes) respectively, observe the incidence of clinical false positives and false negatives in different systems

1.Compared with China-CBI and Global-CBI,  China-TBI and Global-TBI in normal eyes, the cut-off values decreased by 0.28±0.15 (P<0.01) and 0.18±0.15 (P<0.01) respectively. 2. For keratoconus eyes,  no significant change in cut-off values between China-CBI and Global-CBI, China-TBI and Global-TBl. 3. For forme fruste keratoconus eyes, no significant change in the cut-off value between China-TBI and Global-TBl, but the cut-off value between China-CBI and Global-CBI decreased by 0.52±0.34.

Personalized modified CBl and TBI can significantly improve the specificity of clinical keratoconus screening without reducing the sensitivity of keratoconus screening. However, China-TBI still has good sensitivity and specificity for forme fruste keratoconus, while the sensitivity of China-CBI is decreased.