Corneal Stromal Regeneration Treatment In Progressive Corneal Diseases
Published 2024 - 42nd Congress of the ESCRS
Reference: PO780 | Type: Free paper | DOI: 10.82333/qb3k-p636
Authors: Faruk Semiz* 1 , Njomza Hima Musa 1 , Gamze Tanriverdi 2 , merjem purelku 2 , Ceren Ece semiz 1 , Fetih Furkan Arslan 3
1ophthalmology,Eye Hospital,pristina,Kosovo, 2Embriyology an Histology,Istanbul university-Cerrahpasa,Istanbul,Türkiye, 3ophthalmology,Istanbul university-Cerrahpasa,Istanbul,Türkiye
Purpose
To investigate the development of new intrastromal histological structures using transmission electron microscopy after fresh myopic human lenticular implantation with stem cells and telocytes in advanced keratoconus
Setting
Eye Hospital,Pristina,Kosovo
Methods
Sixty eyes with advanced keratoconus indicated for corneal transplantation were included in this study. Fresh myopic lenticular implants were placed in all eyes through SMILE surgery. Lenticular implants were extracted from patients with myopic refractive errors of the cornea, untreated keratoconus, and treated keratoconus following 1, 2, and 3 years of surgery. These five lenticular samples were examined under the electron microscope and compared.
Results
Healthy keratocytes and telocyte-like cells were observed in samples obtained three years after lenticular implantation. The preoperative CDVA improved from 0.86 ± 0.22 logMAR to 0.47 ± 0.09 logMAR (P< .001). The preoperative CCT increased from 399 ± 13.29 μm to 482.10 ± 8.12 μm (P< .001).
Conclusions
Stromal regeneration seems possible in patients with Keratoconus with stem cells and Telocytes.
ClinicalTrials.gov Identifier: NCT04591587