ESCRS - PO773 - Correlation Between Changes In Corneal Biomechanics And Changes In Corneal Density In Portuguese Teenagers – Oporto Myopia Study

Correlation Between Changes In Corneal Biomechanics And Changes In Corneal Density In Portuguese Teenagers – Oporto Myopia Study

Published 2024 - 42nd Congress of the ESCRS

Reference: PO773 | Type: Free paper | DOI: 10.82333/ztt2-bv50

Authors: Daniela Figueiredo Pires* 1 , Ana Sofia Martins 1 , João Heitor Maques 2 , Paulo Sousa 1 , Saul Pires 1 , Renato Ambrósio 3 , Pedro Menéres 2 , João Melo Beirão 2 , Pedro Manuel Baptista 2

1Ophthalmology Department,Centro Hospitalar Universitário do Porto,Porto,Portugal, 2Ophthalmology Department,Centro Hospitalar Universitário do Porto,Porto,Portugal;Instituto de Ciências Biomédicas Abel Salazar (ICBAS),Porto,Portugal, 3Rio de Janeiro Corneal Tomography and Biomechanics Study Group,Rio de Janeiro,Brazil;Department of Cornea and Refractive Surgery,Instituto de Olhos Renato Ambrósio,Rio de Janeiro,Brazil;Federal University of São Paulo (UNIFESP),São Paulo,Brazil;Brazilian Study Group of Artificial Intelligence and Corneal Analysis - BrAIN,Rio de Janeiro,Brazil;Department of Opthalmology,Federal University of the State of Rio de Janeiro (UNIRIO),Rio de Janeiro,Brazil

Purpose

To describe the changes in corneal biomechanics and corneal density analysis in a cohort of Portuguese teenagers and to correlate the changes in corneal biomechanics and changes in corneal densities during the follow up.

Setting

Unidade Local de Saúde de Santo António, Porto, Portugal

Methods

This is a prospective cohort study. Data was collected from 2 timepoints, spaced by 2.4(+-0.3) years. Corneal biomechanics were assessed in both timepoints, by means of Scheimpflug image, with Corvis ST (OCULUS, Germany). Both 1st and 2nd generation parameters were assessed, including the new TBI V2 and Stiffness parameter in highest concavity (SP-HC). Corneal density data was assessed in both timepoints, by means of Scheimpflug image, with Pentacam HR (OCULUS, Germany). Deltas from the parameters from both corneal biomechanics and corneal density assessments were built, and Pearson linear correlation coefficients were calculated for the deltas parameters.

Results

The present study included 126 eyes from 63 individuals, with a mean age at baseline of 14.2(+-2.6) years old. The change in the average density of the total cornea was correlated with changes in 6 corneal biomechanical parameters: pachy [µm], HC Deflection Length [mm], Whole Eye Movement Max [mm], PachySlope [µm], Ambrósio Relational Thickness over the horizontal meridian (ARTh) and Corvis Biomechanical factor (CBI).

Conclusions

The present study found an association between the change in corneal biomechanical parameters and corneal density among teenagers during a follow-up of more than 2 years. This is the first report of this association in adolescents. These findings could pave the way for future algorithms to apply in clinical practice, including both Scheimpflug image derived corneal biomechanics and corneal density analysis. More studies are needed to strengthen these conclusions.