Intrastromal Decellularized Porcine Corneal Lenticular Implantation (36 Months Follow Up)
Published 2024 - 42nd Congress of the ESCRS
Reference: PO759 | Type: Free paper | DOI: 10.82333/b3by-5b84
Authors: Ahmed A K Elmassry* 1 , Shahira Rashad 1 , Mones Abdallah 1
1Ophthalmology,faculty of Medicine,Alexandria,Egypt
Purpose
To evaluate the efficacy of implanting decellularized Porcine lenticule (XENIA Implant) in a femtosecond laser assisted constructed pocket for management of advanced Keratoconus with clear cornea
Setting
ØA prospective , non randomized, non comparative , interventional, case series on seven eyes of six patients (three eyes females and three eyes males) .
ØSix of them were eyes of advanced Keratoconus, and one eye was advanced Post-LASIK Ectasia.
ØThe study started in July 2019 and currently has follow up of at least 36 months.
The study was done in Roayah Vision Center in Alexandria Egypt
Methods
ØThe patients were subjected to femtosecond assisted laser pocket creation using Visumax Zeiss. Meditec Machine.
ØThe Porcine lenticules are produced by Gebauer Medical , extracted from Porcine tissue, subjected to a decellularization process, and intensely cross linked.
ØThe lenticule is a clear 7 mm tissue with a thickness between 100 & 120 microns .
Results
The mean age of the patients was 27.67+/- 9 years.
All surgical procedures were uneventul.
Five eyes completed three years of Follow up
No episodes of rejections were encountered
Improvement of visual Acuity in all patients at 6,12 months and three years
The mean Central Corneal Thickness measeured by ultrasound increased after measeurment at one month, one year and three years.
Corneal hysteresis, Coma , Spherical aberreations were improved
Mean K values improved from 55.64 D to 52.15 D after one year.
All cases were cross linked three months after surgery except the case of post lasik corneal ectasia.
Conclusions
the advantaged of Xenia Implants include:
ØShort learning curve.
Ø Ease of Implantation.
Ø Immunologically safe after 36 months follow up.
Ø Still reversible.
Ø Good visual and aberrometric outcomes.
Ø Could save the other eye more rapidly ; by early implantation. No need to wait for three months for the other eye.
ØTissue augmentation with decellularized Porcine lenticules (XENIA Implants) and Corneal cross-linking results in improvement in
Visual acuity.
Corneal Curvature.
In corneal hysteresis.
Decreased Corneal higher order aberrations.
- Three years follow up , confirmed the transparency, and Immunologically Stable Implants, improvement of Pentacam readings, increased thickness by U/S pachymetry.