Ilusy+ Study: Spectacle Independence And Visual Quality Of Life After Bilateral Implantation Of Synthesis Plus Versus Monofocal Lens

To compare patients’ spectacle independence, quality of life and satisfaction after implantation of the Synthesis PLUS, an EDOF IOL versus monofocal IOLs.

Rennes-University-Hospital and Lorient Hospital; France. 

Nineteen patients underwent bilateral Synthesis PLUS IOL implantation, and thirty-five bilateral implantation of monofocal IOL. Best-corrected distance visual acuity (CDVA), uncorrected distance visual acuity (UDVA) at 4 meters, corrected (CNVA) and uncorrected near visual acuity (UNVA) at 33cm, were assessed at 1 and 6 months after the surgery. Defocus curves and Pelli-Robson contrast sensitivity test in photopic conditions were performed 1 month postoperatively.  Patients-reported spectacle independence was inquired by the PRSI-Q, and visual function and satisfaction by the Catquest-9SF, preoperatively, and at 1 and 6 months postoperatively. A p-value lower than 0.05 was considered statistically significant.

The mean UDVA (p=0.0523), CDVA (p=0.53) and contrast sensitivity (p=0.9248) did not differ between groups. The UNVA was significantly better in the Synthesis PLUS group (0.39±0.18 vs 0.63±0.16 p<0.0001). The defocus curves show an extended-depth of focus of 2D for a visual acuity better than 0,3 logMAR. Spectacle independence was significantly higher for intermediate (p=0.0002) and near vision (p=0.0006), with a better visual comfort in the Synthesis PLUS group, and a higher global satisfaction (p=0.0155).

The Synthesis Plus IOL provides an extended depth-of-focus, and an UNVA significantly higher than monofocal IOLs, not counterbalanced by a loss of contrast sensitivity and distance visual acuity. As a result, it enhances spectacle independence, particularly in social settings, and lead to higher overall satisfaction among patients.