ESCRS - PO396 - Short-Term Impact Of Hypertonic Solution On Early Recovery After Cataract Surgery

Short-Term Impact Of Hypertonic Solution On Early Recovery After Cataract Surgery

Published 2024 - 42nd Congress of the ESCRS

Reference: PO396 | Type: Free paper | DOI: 10.82333/fvdn-7a83

Authors: Nicolas Alejandre* 1 , Natalia Lorenzana 2 , Gonzalo Velarde 1

1Ophthalmology,Universitary Hospital Fundación Jiménez-Diaz,Madrid,Spain, 2Ophthalmology,University hospital Foundation Jimenez-Diaz,Madrid,Spain

Purpose

To assess the changes in corneal thickness among patients experiencing corneal edema after cataract surgery who were treated with a hypertonic ophthalmic solution in the immediate postoperative period.

Setting

Hospital Universitario Fundación Jiménez Díaz. Madrid, Spain

Methods

This prospective, non-comparative study included 40 eyes of 40 patients (25 females [62.5%] and 15 males [37.5%]; mean age: 75.18±8.21 years old) with grade 2 to 4 corneal edema after cataract surgery. Patients were examined first within 24 hours after surgery. Subsequently, they received a hypertonic ophthalmic solution (AEON sodium chloride 5%; Rayner Surgical, Worthing, UK) and were re-examined 2 hours after instillation.

Examinations included corneal pachymetry measured by optical coherence tomography (OCT) and Pentacam and distance visual acuity using a pinhole occluder.

Results

Mean pachymetry measured by OCT decreased significantly from 762.0±87.8 µm to 745.0±92.3 µm 2 hours after receiving the ophthalmic solution (p=.016). Mean maximum pachymetry decreased from 838.0±89.2 µm to 817.0±94.8 µm (p=.008) and mean minimum pachymetry from 676.0±89.9 µm to 671.0±80.2 µm (p>.05). Pachymetry at pupillary center, apex and thinnest point measured by Pentacam decreased from 863.0±161.0 µm to 833.0±169.0 µm (p=.022), from 861.0±156.0 µm to 824.0±167.0 µm (p=.002), and from 617.0±64.2 µm to 553.0±109.8 µm (p=.001), respectively. Visual acuity increased from 0.61±0.46 logMAR to 0.51±0.42 logMAR, where an improvement was observed in 16 eyes (40.0%), no change in 23 eyes (57.5%), and a reduction in one eye (2.5%).

Conclusions

In patients with corneal edema following cataract surgery, a significant reduction in corneal thickness was observed 2 hours after administration of the hypertonic ophthalmic solution AEON. In addition, postoperative distance visual acuity improved or was stable in most cases. A comparative study would be useful to conclusively evaluate the promising effect of this hypertonic ophthalmic solution on postoperative corneal edema. By the time of the abstract the data has been submitted for peer-review publication.