Hyperosmolarity Causes Increased Variation Of Light Scatter Following Cataract Surgery
Published 2024 - 42nd Congress of the ESCRS
Reference: PO390 | Type: Free paper | DOI: 10.82333/7dbq-5h26
Authors: Lisa Nijm* 1 , Benjamin Sullivan 2 , Marta Palazon 3 , Ines Yago 3 , Raúl Duarte 4 , Julie Schallhorn 5 , Darrel White 6 , Michael Berg 2 , Pablo Artal 4
1Department of Ophthalmology and Visual Sciences,University of Illinois Eye and Ear Infirmary,Chicago,United States, 2Trukera Medical,Southlake,United States, 3Oftalmología en Murcia,Hospital Universitario Virgen de la Arrixaca,Murcia,Spain, 4Laboratorio de Optica,Universidad de Murcia, Campus de Espinardo,Murcia,Spain, 5Francis I. Proctor Foundation and Department of Ophthalmology,University of California, San Francisco,San Francisco,United States, 6SkyVision Centers,Westlake,United States
Purpose
To study the association between hyperosmolarity and ocular light scatter in a cataract surgery population.
Setting
Hospital Clínico Universitario Virgen de la Arrixaca, Murcia, Spain.
Methods
In a prospective, observational study, contiguous, 20 second ocular scatter index (OSI) scans were recorded in hyperosmolar (≥ 308 mOsm/L) and normal subjects (< 308 mOsm/L) with cataract nuclear opacity ≥ 3. OSI was measured at screening, baseline and 90 days following surgery. Along with symptoms of ocular surface disease, slit lamp examination included corneal staining (0–3), tear film breakup time (TBUT) and evaluation of meibomian gland disease (MGD). An additional cohort of hyperosmolar subjects were measured for OSI at screening, baseline, and 5, 10, 15 & 30 minutes following instillation of 0.18% sodium hyaluronate.
Results
31 eyes of 31 patients were included. There was a significant difference in post-operative OSI variation when comparing hyperosmolar (0.65±0.30, N=11) to normal subjects (0.33±0.11, N=10, p=0.005). Of note, there were no significant differences in OSI variation when subjects were sorted by staining (p=0.891), TBUT (p=0.749), symptoms (p=0.719), or MGD status (p=0.852). Instillation of 0.18% HA (N=10) did not alter OSI at 5 minutes, but significant reductions in OSI of 28.8%, 38.5% and 36.7% (all p < 0.001) were observed at 10, 15 and 30 minutes.
Conclusions
Hyperosmolar patients exhibited significantly increased variation in light scatter following cataract surgery that was undifferentiated by staining or TBUT. Hyperosmolarity may be indicative of tear film instability leading to greater light scatter equivalent to that of a grade 2–3 cataract.