Unveiling The Impact Of Aqueous Antioxidants On Posterior Capsule Opacification After Cataract Surgery
Published 2024 - 42nd Congress of the ESCRS
Reference: PO383 | Type: Poster | DOI: 10.82333/9940-a992
Authors: Jin-Jhe Wang* 1 , Chen-Wei Lin 2 , Yu-Ting Tsao 3 , Yi-Jen Hsueh 4 , Hung-Chi Chen 5
1Department of Ophthalmology,Chiayi Chang Gung Memorial Hospital,Chiayi,Taiwan, Province of China, 2Department of Ophthalmology,Chiayi Chang Gung Memorial Hospital,Chiayi,Taiwan, Province of China;Department of Medical Education,Chiayi Chang Gung Memorial Hospital,Chiayi,Taiwan, Province of China, 3Department of Ophthalmology,Chang Gung Memorial Hospital,Linko,Taiwan, Province of China, 4Department of Ophthalmology,Chang Gung Memorial Hospital,Linko,Taiwan, Province of China;Center for Tissue Engineering,Chang Gung Memorial Hospital,Linko,Taiwan, Province of China, 5Department of Ophthalmology,Chang Gung Memorial Hospital,Linko,Taiwan, Province of China;Department of Medicine,Chang Gung University College of Medicine,Taoyuan,Taiwan, Province of China;Center for Tissue Engineering,Chang Gung Memorial Hospital,Linko,Taiwan, Province of China
Purpose
With the widespread prevalence of cataract surgery, the issue of postoperative posterior capsule opacification (PCO) is garnering attention. This study aims to investigate the effect of aqueous total antioxidant capacity (TAC) and ascorbic acid (AA) on the incidence of visual-threatening PCO following cataract surgery.
Setting
In our prior publications, we have demonstrated that the antioxidant capacity of the aqueous humor, primarily attributed to AA, has the potential to delay age-related changes and inhibit the formation of cataracts in the lens. Our current research is focused on investigating the effect of aqueous antioxidants on the occurrence of PCO following cataract surgery within our cohort.
Methods
This retrospective cohort study recruited 117 subjects who underwent phacoemulsification with intraocular lens implantation at Chang Gung Memorial Hospital between September 2017 and November 2022. Following surgery, patients were monitored for the development of PCO and categorized into two groups. The study group consisted of 19 eyes that developed PCO necessitating Nd:YAG capsulotomy, while the control group comprised 98 eyes without PCO formation. Aqueous humor samples were collected intraoperatively and assessed for TAC and AA levels using the ferric reducing/antioxidant AA (FRASC) assay. Demographic data, systemic diseases, and ocular comorbidities were obtained and analyzed.
Results
The levels of aqueous TAC and AA were found to be significantly higher in the study group compared to the control group (1.82 ± 0.31 mM vs. 1.49 ± 0.52 mM, p = 0.01 and 1.45 ± 0.29 vs. 1.10 ± 0.44, p = 0.0006, respectively). Furthermore, both aqueous TAC and AA levels emerged as independent risk factors for PCO formation, with adjusted odds ratios of 18.06 (p = 0.002) and 69.65 (p < 0.001), respectively.
Conclusions
Aqueous TAC and AA may be significant factors influencing the incidence of vision-threatening PCO after cataract surgery. Further research is warranted to elucidate the underlying mechanisms and explore potential strategies for PCO prevention and treatment, thereby enhancing clinical outcomes and patient quality of life.