Evaluation Of Intravitreal Injections As A Risk Factor For Capsular Rupture During Cataract Surgery
Published 2024 - 42nd Congress of the ESCRS
Reference: PO382 | Type: Free paper | DOI: 10.82333/j782-nh61
Authors: Thomas Falb 1 , Christoph Singer 1 , Magdalena Holter 2 , Lisa Eder 1 , Manuel Grosspötzl 1 , Martin Weger 1 , Ewald Lindner 1 , Andrea Berghold 3 , Christoph Mayer-Xanthaki 1 , Anton Haas 1 , Jakob Gran* 1 , Andreas Wedrich 1
1Ophthalmology,University Clinic Graz,Graz,Austria, 2Medical Informatics,University Clinic Graz,Graz,Austria, 3Institute for Medical Informatics, Statistics and Documentation,Medical University of Graz,Graz,Austria
Purpose
To determine whether previous intravitreal injections are an independent risk factor for posterior capsular rupture (PCR) during cataract surgery after adjusting for known risk factors.
Setting
Single-center medical records analysis of a population-based cohort at a university-based referral center.
A retrospective cohort study has been conducted with inclusion of cataract surgeries done from January 1, 2006 to December 31, 2020 at the Department of Ophthalmology, Medical University of Graz, Austria.
Methods
Association between previous intravitreal injections and PCR rates has been analyzed through univariable and multivariable generalized estimating equations (GEE). Other investigated risk factors were age, combined surgery, pseudoexfoliation, surgeon’s experience and type of cataract surgery.
Results
A statistically significant higher rate of posterior capsular rupture during cataract surgery has been found in patients with previous intravitreal therapy compared to patients with no history of intravitreal therapy (OR 1.27, 95% CI 1.10 – 1.46, p = .008). However, after adjusting for confounding risk factors, no statistically significant effect was seen (OR 1.04, 95% CI 0.89 – 1.21, p = .664).
Conclusions
No association between history of intravitreal injections and PCR during cataract surgery was found after adjusting for known risk factors. Further studies upon interactions between history of intravitreal injections and known risk factors for PCR, especially pseudoexfoliation, are warranted.