Localized Recurrent Corneal Erosion Secondary To Intracorneal Deposit In Patient With Long Use Of Quetiapine Tablet

To describe a rare ocular side effect of quetiapine medication which is classified as antipsychotic used to treat a variety of mental illnesses

describtive findings of  clinical case encounterd during ophthalmic clinical practice.

 We describe a case of a 48-year-old diagnosed with sleeping disorder presented to an ophthalmology clinic with a history of intermittent ocular redness and foreign body sensations for few months. Past history was unremarkable for ocular trauma, use of any topical ocular medication, or corneal hereditary disorders. The patient was diagnosed with insomnia, for which oral quetiapine  has been prescribed for the last seven years. Slit lamp examination revealed an intracorneal inferior paracentral deposit of multiple white materials with distinct borders reaching deeper layers of the corneal stroma with a superficial part causing disruption of corneal epithelium leading to localized corneal erosion that necessitate removal of superficial part. 

Quetiapine is an antipsychotic medication with multiple reported ocular side effects including central serous chorioretinopathy, branch retinal vein occlusion, cataract, blurring of vision. Intracorneal deposit with recurrent corneal erosions  was not reported before as shown in this case, which is most likely to be secondary to chronic use of quetiapine.

Recurrent corneal erosion can be one side effect of systemic medication than can lead to ophthalmic manifestation