ESCRS - PO277 - Epithelial Thickness And Quality Of Vision In Dry Eye Patients Before And After Trehalose And Hyaluronic Acid Treatment

Epithelial Thickness And Quality Of Vision In Dry Eye Patients Before And After Trehalose And Hyaluronic Acid Treatment

Published 2024 - 42nd Congress of the ESCRS

Reference: PO277 | Type: Free paper | DOI: 10.82333/qby6-zv54

Authors: Maria A. Henriquez* 1 , Ignacia Zenteno 1 , Rolando Rojas 1 , Luis Izquierdo Jr 2

1Research Department,Oftalmosalud Institute of Eyes,Lima,Peru, 2Research Department,Oftalmosalud Institute of Eyes,Lima,Peru;San Fernando School of Medicine,Universidad Nacional Mayor de San Marcos,Lima,Peru

Purpose

To evaluate corneal epithelial thickness and quality of vision in patients with dry eye disease (DED) before and after treatment with Thealoz Duo (trehalose [3%] and Hyaluronic Acid [0.15%]).

Setting

Oftalmosalud, Instituto de Ojos, Lima, Peru.

Methods

Prospective cohort study, including 30 DED eyes treated with trehalose [3%] and Hyaluronic Acid [0.15%] eye drops four times daily for 3 months between September 2023 to February 2024 at Oftalmosalud, Lima, Peru. Pre and post-treatment evaluations at 1 and 3 months included: Ocular Surface Disease Index (OSDI) questionnaire, invasive tear break-up time (BUT), Corneal fluorescein staining score (Oxford grading scale), tear meniscus height (TMH), Non-invasive BUT (NIBUT, Keratograph 5M [Oculus, Wetzlar, Germany]), Visual Acuity, epithelial thickness (ET) profile (Anterion, OCT), quality of vision by measuring objective light scatter index (OSI) and MTF (modular transfer function using the HD Analyzer).

Results

Mean pre and post-treatment at 1 m (Post-1m) NIBUT was 4.54 +/- 2.01 and 6.39 +/- 3.19 seconds (p <.001), mean pre and Post-1m OSDI score were 25.28+/- 8.08  and 19.89 +/- 6.30 (p <.001), mean ET was 48.43 um and 48.83 um (p = 0.12), mean minimum ET was 39.43 +/- 3.44 um and 40.36 +/- 4.18 um (p= 0.04), mean ET inferior-superior asymmetry was 2.56 and 2.43 (P= 0.47). Mean pre and post-1m OSI index was 1.63 +/- 1.59 and 1.51 +/- 1.16 (p= 0.90) and mean pre and post-1m MTF was 26.69 +/- 13.48 and 27.54 +/- 12.48 (p= 0.62). 

Conclusions

The thinnest corneal epithelium became thicker after treatment in dry eye patients.