Topographic Anterior Segment Parameters In Patients With Graves' Ophthalmopathy And The Relationship Between These Parameters And Thyroid Function
Published 2024 - 42nd Congress of the ESCRS
Reference: PO263 | Type: Free paper | DOI: 10.82333/cw17-3432
Authors: Erdi Karadag* 1 , Raziye Dönmez Gün 1 , Murat Oklar 1 , Güzide Akçay 1 , Naile Gökkaya 2
1Ophthalmology,Kartal Dr.Lütfi Kırdar City Hospital,Istanbul,Türkiye, 2Internal Medicine,Kartal Dr.Lütfi Kırdar City Hospital,Istanbul,Türkiye
Purpose
Graves' ophthalmopathy (GO) is an example of thyroid dysfunction that causes structural and functional changes in the eye. The aim of this study was to evaluate the effect of GO on topographic anterior segment parameters and the relationship between thyroid function and these parameters.
Setting
This is a retrospective cross-sectional study conducted between January 2022 and January 2023 at a tertiary referral centre.
Methods
The study compared anterior segment parameters, including central corneal thickness (CCT), anterior chamber depth (ACD), anterior chamber volume (ACV), and iridocorneal angle (ICA), measured using Sirius® topography (CSO, Firenze, Italy), in eyes with GO (Group 1, 41 eyes of 41 patients) compared to healthy controls (Group 2, 33 eyes of 33 patients).The study analysed the relationship between these parameters and the participants' plasma levels of Thyroid Stimulating Hormone (TSH), free T3 (fT3), free T4 (fT4), antithyroid peroxidase (TPO), Thyroid Stimulating Immunglobulin (TSI) and antithyroglobulin (anti TG). The study excluded patients who were under 18 years old, pregnant,or had prior thyroid or eye surgeries, or had corneal disorders.
Results
There was no significant difference between the groups in terms of mean age (40.8±15.4 and 36.8±7.6 years in Groups 1 and 2, respectively) and gender (28 and 22 females in Groups 1 and 2, respectively) (p>0.05). CCT, ACD, ACV and ICA were 536±33 and 534±33 μm, 3.38±0.44 and 2.96±0.35 mm, 150±38 and 134±27 μL and 41±8 and 37±6° in Groups 1 and 2, respectively. In group 1, ACD and ICA values were found to be significantly higher than controls (p<0.001 and p=0.023, respectively). CCT was correlated negatively with TSH and positively with TPO and fT3 (p<0.05). TSI was negatively correlated with ACD, ACV and ICA (p=0.003 for each).
Conclusions
Eyes with GO may have higher anterior segment parameters compared to healthy eyes, and thyroid function may affect ACD and ICA. In clinical practice, it is important to request details and tests showing the thyroid function of patients when anterior segment parameters are affected.