Quantitative Analysis Predicting Glaucoma Progression Using Optical Coherence Tomography Angiography Vessel Density And Severity Of Visual Field Loss In Glaucoma
Published 2024 - 42nd Congress of the ESCRS
Reference: PO252 | Type: Free paper | DOI: 10.82333/zj4t-y650
Authors: Amira Bouayad 1 , Chaimae Khodriss* 1 , Alouadi Achraf 1 , Elbahloul Meriem 1
1Ophthalmology department,Mohamed VI University Hospital,tangier,Morocco;Abdelmalek Essaadi University,tangier,Morocco
Purpose
To evaluate the quantitative association between vessel density measurements using optical coherence tomography angiography (OCT-A) and severity of visual field loss in glaucoma.
Setting
Ophthalmology department, Mohamed VI university hospital of tangier,Morocco
Methods
An observational, cross-sectional study including glaucoma patients. All patients underwent a complete ophtalmological examination with imaging using OCT-A, spectral-domain OCT (Cirrus 6000,Zeiss), and standard automated perimetry (SAP). Patients with glaucoma were additionally classified into 2 groups based on the severity of their visual field damage. Retinal vasculature information was summarized as vessel density(VD), that is the percentage of area occupied by flowing blood vessels in the macular and peripapillar region. Two measurements from the retinal vasculature were used: 4,5mm 4,5mm scan in optic nerve head (ONH) and 3mm 3 mm scan in the macular region (MAC). And the measurements of VD was calculated with ImageJ software.
Results
A total of 140 eyes from 30 healthy participants, 14 glaucoma suspects, and 96 glaucoma patients were included. Mean Age was 60.73± 11.026 ; and MD was -6.42±5.42 in glaucoma eyes. Macular and papillar Vessel density in normal eyes was higher, followed by glaucoma suspects, mild glaucoma, and moderate to severe glaucoma eyes (53.1%, 49,8%, 45.9%, and 40.7%, respectively for ONHVD) (P < 0.005) and for MACVD (38.8%, 36.9%, 35,8%,32,3%, respectively) (P < 0.005). In addition, we found a significant association between vessel density, age, intraocular pression and papillar excavation.
Conclusions
Decreased macular and papillar vessel density was quantitatively significant associated with the severity of visual field damage. Optical coherence tomography angiography is a promising technology in glaucoma management, potentially enhancing the understanding of the role of vasculature in the pathophysiology of the disease.