Insulin Eye Drops For The Treatment Of Superficial Punctate Keratitis And Persistent Corneal Epithelial Defect

 

case series of 3-patients, 2 with resistant SPK and a patient with PED healed with insulin eye drops. 

Case1. A 64-year-old woman with a history of RA and dry eye syndrome uncontrolled by various topical treatments was referred for a new treatment option. We initiated insulin eye drops treatment qDt , Following 1 month treatment, a marked objective and subjective improvement of the SPKS was observed.

Case 2: A 74 year-old man with a history of complicated cataract surgery with dropped nucleus and AC-IOL implantation and hospitalization due to corneal ulcer that was treated with fortified antibiotics, presented with resistant SPKS that didn’t healed for 3 months under autologous serum treatment. treatment with qDt insulin eye drops was initiated. At 1 month follow up there was a complete healing of the SPK with marked subjective improvement. 

Case 3. A 62-year-old woman with a history of severe systemic scleroderma associated dry eye, was referred for severe left eye visual impairment and pain due to persistent central corneal epithelial defect following an iatrogenic corneal epithelial scraping during a PPV procedure for bunny lens fixation.  The epithelium was unresponsive to various treatment regimens including autologous serum and bandage contact lens. The patient commenced on a novel treatment with insulin eye drops and was monitored closely. Following 2 months of treatment, a complete healing of the epithelial defect and improvement of visual acuity was observed.