Dry Eye In Sjogren's Syndrome: A Case Report

The purpose of this poster  is to illustrate  the efficacy of eye drops  and amniotic membrane transplant  in treatment of corneal ulcer in a person  suffering from gougerot syndrome

central military hospital of the army of Algeria

Sjögren’s syndrome (SS) is a common autoimmune disease affecting about four million Americans. Although approximately 1 in 10 patients with clinically-significant aqueous deficient dry eye has underlying SS.We report the clinical presentation, and management of a woman diagnosed with jögren syndrome who suffered from severe DED sequelae. The patient has been followed for 08 years for chronic open-angle glaucoma in both eyes under hypotonizing treatment The patient also complain about polyarthralgia and fatigue. From physical examination, red eyes were found. Laboratory showed Hb13.7 g/dl, leukocyte 5840/μl, thrombocyte 232.000/μl, ureum 17 mg/dl, creatinin 0.72 mg/dl, ANA4.3, rheumatoid factor negative, hepatitis C and HIV test negative, CRP < 0.7, autoantibodies examination SSA and SSB are positive. Ocular examination Schirmer test 4 mm in 5 m in both eyes.The slit lamp examination showed central corneal  pre perforation measuring 2×2 mm with a negative  Seidel test ine right eye The case was managed first by multiple attempts to seal the defect with cyanoacrylate glue, and then a patch corneal graft was performed as the anterior chamber failed to deepen.in the right eye the exam found a central corneal manged with a antibioyioc cotyocoid then ciclosporine marked by a good clinical evolution

After diagnosing Sjögren syndrome, treatment is aimed at maintaining the integrity of the tear film through preservation, augmentation, and/or replacement of the deficient tear secretion. luid-ventilated, gas permeable scleral lenses have been successful in treating severe ocular surface diseases including Sjögren syndrome. For many years, systemic corticosteroids have been used in a variety of inflammatory conditions. Due to limited efficacy and high incidence of complications, they are not widely used in Sjögren syndrome. Topical corticosteroids are widely available in a variety of dosages, often combined with antibiotics and preservatives, and may be useful for short-term treatment of ocular surface inflammatory conditions.