Validation Of A New Spectral-Domain Optical Coherence Tomography-Based Biometer (Vemos-Axl) Designed For The European Project Vemos
Published 2024 - 42nd Congress of the ESCRS
Reference: PO1254 | Type: Poster | DOI: 10.82333/gjqs-xp32
Authors: Jorge L Alio* 1 , Marina José-Martinez 2 , Antonio Martinez-Abad 2 , Alejandra E Rodriguez 2 , Francesco Versaci 3 , Joaquim Murta 4 , Ana Belen Plaza-Puche 2 , Mario Canto-Cerdan 2 , David Piñero 5 , Jesper Hjortdal 6
1Research and Development,Vissum Miranza Alicante,Alicante,Spain;Pathology and Surgery,Miguel Hernandez University,Alicante,Spain, 2Research and Development,Vissum Miranza Alicante,Alicante,Spain, 3CSO (Construzioni Strumenti Oftalmici),Firenze,Italy, 4Department of Ophthalmology,University of Coimbra,Coimbra,Portugal, 5Department of Optics, Pharmacology and Anatomy,University of Alicante,Alicante,Spain, 6Department of Ophthalmology,Aarhus University Hospital,Aarhus,Denmark
Purpose
The VEMoS Project is a system that virtually reconstructs the patients´ eye using biometric data extracted from the VEMoS-AXL device designed specifically for this project. The validation of these devices is crucial in order to predict pre-operative and postoperative outcomes for refractive surgery treatment. VEMoS-AXL is a new optical biometer based on spectral domain optical coherence tomography (SD-OCT) that has been tested in terms of intrasession repeatability and compared with a swept-source optical coherence tomography biometer (SS-OCT). The purpose of this study is to investigate the reliability of the biometric measurements provided by this new system and analyze the agreement with those obtained with the gold standard SS-OCT
Setting
Vissum Grupo Miranza, Alicante, Spain.
Methods
The study included 120 eyes of 120 patients, randomly selected and aged between 18 and 40 years. A complete ophthalmologic examination was carried out to all patients involving the IOLMaster 700(Zeiss) and the VEMoS-AXL(CSO). The normality of data distributions was confirmed by the Kolmogorov-Smirnov test. The unpaired Student t test was used for comparing the instruments in each parameter. Pearson coefficient was calculated to assess the correlation between parameters measured with each device. Intrasession repeatability was analyzed using the intraclass correlation coefficient (ICC) and the within-subject standard deviation(Sw). Bland-Altman analysis evaluated the interchangeability of both devices to measure the anatomical parameters
Results
The ICC for the six consecutive measurements of AL performed by VEMoS-AXL was 0.994 (p < 0.001) and the Sw was 0.02. Comparison of AL measured with VEMoS-AXL and IOL-Master did not show significant differences. The correlation of AL measures with both devices was very strong (r=0.994, p<0.001). For CCT measurements, statistically significant differences were found between both devices. Despite the statistical disparities observed in the differences found, the correlation between both devices was strong (r=0.990, p<0.001). Statistically significant differences were found between the ACD measurements obtained with the two biometers evaluated although correlation of these measurements was also strong and significant.
Conclusions
The new optical biometry system VEMoS- AXL from CSO provides consistent measures of AL, ACD and CCT in healthy eyes. AL and pachymetric measurements can be used interchangeably with those obtained with the SS-OCT-based system IOL-Master 700. This confirms the viability of the clinical use of this new biometer. Special care should be taken with ACD measures of both devices that cannot be used interchangeably, which de-serves more research.
A limitation of the present study is related to the characteristics of the sample using only young subjects without cataracts. Future studies should be also conducted to confirm all these outcomes in eyes with different pathological conditions and after different types of ocular surgeries.