The Effect Of Donor Lenticule Depth On The Results Of Allogeneic Corneal Inlay Treatment For Presbyopia

This study aims to assess the impact of the lenticule's position within the donor cornea on visual, refractive, and topographic outcomes in patients who undergo allogeneic corneal inlay (Allotex Inc.,Boston, MA, USA) implantation.

Department of Ophthalmology, Istanbul Medipol University, Faculty of Medicine, Istanbul, Turkey

Allotex Inc.,Boston, MA, USA

Swiss Vision Clinic, Istanbul, Turkey

This retrospective study included 86 patients with a 6-month follow-up.An allogeneic corneal inlay was implanted in the non-dominant eye of emmetropic patients with presbiyopia.Uncorrected distance (UDVA), uncorrected intermediate (UIVA), uncorrected near (UNVA), corrected distance (CDVA) and distance-corrected near visual acuity(DCNVA), refraction and keratometric values were assessed preoperatively and at 6 months postoperatively.We also analysed the correlation between the depth of the cornea from which the donor lenticule was obtained and the change in these parameters.The patients were divided into three groups according to the depth of the donor lenticule.The changes observed over a period of 6months were compared among 3 groups.

Preoperative UIVA, UNVA, DCNVA were 55.62±10.1, 39.45±7.84, 42.76±7.62 letters, respectively. These values increased to 66.28±7.71, 68.14±5.34, and 61.87±7.04, respectively, at 6 months postoperatively. UDVA and BDVA decreased from 87.41±5.26 to 78.77±6.38 and from 90.72±3.53 to 86.97±3.75, respectively. (all p values <0.05). Preoperative spherical refraction was 0.36 ± 0.30 D and postoperative spherical refraction was -0.45±0.44 D (p<0.05). Keratometric values showed a significant increase (p<0.05). No correlation was found between the change in all parameters and lenticule depth (p>0.05). In the subgroup analysis based on lenticule depth, there was no significant difference between the groups in the change of any parameter (p>0.05).

Allogeneic presbyopic inlay implantation is a successful treatment method for emetropic presbyopes, improving their intermediate and near distance visual acuity. The compromise in distance VA was acceptable. There is no correlation between the depth of the cornea from which the donor lenticule was obtained and the results. For this reason, lenticules obtained from different depths can be used as corneal inlay. Many patients can benefit from a single donor cornea, making it a valuable resource.