A Study Of Clinical Features Between Persistent Hyperplastic Primary Vitreous Combined With Cataract And Congenital Fibrovascular Pupillary Membrane

To analyze the clinical features between persistent hyperplastic primary vitreous (PHPV) and congenital fibrovascular pupillary membrane (CFPM).

This is a single center retrospective, observational study. 

This retrospective study compared ocular biometric parameters, including anterior chamber depth (ACD),  axial length (AL),  corneal diameter (CD) in the affected eyes (AEs)  and  the fellow eyes (FEs), clinical features and morphological changes of fibrovascular membrane (FM) in children with PHPV and CFPM who received surgery. Children in PHPV combined with cataracts  received cataract extraction and anterior vitractomy, while  children in  CFPM group only received remove of FM. 

It was included 56  (61 eyes) of PHPV and 24  (25 eyes) of CFPM. PHPV combined with cataract and other ocular abnormalities, but CFPM mainly presented blockage  and abnormalities in pupillary area. In unilateral cases of them, the ACD of AEs was smaller than that of the FEs, and in under-24-month-old subgroup, the AL  of AEs was smaller than that of the  FEs (P<0.05). The CD of the AEs in PHPV group was smaller and the IOP was higher than those in the FEs (P<0.05); but there were no significant differences in CFPM group. The ACD of AEs  in PHPV group was significantly smaller than that of CFPM group (P<0.05). The FM  in PHPV group was in the opacity of lens; while in CFPM group it  was in the iris adhering to the lens anterior capsules.

PHPV and CFPM have the similar clinical features, suggesting that they are different variants of persistent fetal vasculature (PFV). However, PHPV had a wider range of lesions and more complex conditions.