Efficacy And Safety Profile Of Ab-Interno Canaloplasty Performed With And Without Gatt In Uncontrolled Glaucoma Eyes – 24 Month Outcomes

To investigate the outcomes of ab-interno canaloplasty with the iTrack microcatheter (Nova Eye Medical, Fremont, USA.) performed as a standalone procedure, or in combination with gonioscopy-assisted transluminal trabeculotomy (GATT).

A single-center retrospective case series.

Patients with uncontrolled (≥18mmHg) moderate or severe primary open-angle glaucoma and no history of glaucoma surgery, except for SLT or CPC, underwent treatment with either iTrack or iTrack+GATT. All eyes except 1 underwent canaloplasty combined with phaco. Primary endpoints were mean intraocular pressure (IOP) and mean number of medications at 12-24 months.

Twenty-one eyes (5 iTrack and 16 iTrack+GATT) were included. Mean baseline IOP (mmHg) was 24±4.6 (iTrack) and 21.8±5.2 (iTrack+GATT) and the number of glaucoma medications was 1.4±0.5 and 2.3±0.9 respectively. At 24 months, mean IOP reduced to 12.8±1.2 (iTrack; -47%) and 11.8±2.7 (iTrack+GATT; -46%) and medication use was 1.4±1.4 (no change) and 1.3±0.5 (-42%) respectively.

In eyes with uncontrolled glaucoma, canaloplasty resulted in a sustained and comparable reduction in IOP when performed as a standalone procedure or with GATT. Canaloplasty combined with GATT also resulted in a reduction of glaucoma medications.