ESCRS - PO090 - Refractive Lens Exchange With An Extended Depth Of Focus Intraocular Lens In Fuchs Endothelial Dystrophy

Refractive Lens Exchange With An Extended Depth Of Focus Intraocular Lens In Fuchs Endothelial Dystrophy

Published 2024 - 42nd Congress of the ESCRS

Reference: PO090 | Type: Case Report | DOI: 10.82333/mq5j-y389

Authors: Ziqiao Qi* 1 , Mayank A. Nanavaty 2

1Eastbourne District General Hospital,Eastbourne,United Kingdom, 2Sussex Eye Hospital, University Hospitals Sussex NHS Foundation Trust,Brighton,United Kingdom;Brighton & Sussex Medical School,Brighton,United Kingdom;Eastbourne District General Hospital,Eastbourne,United Kingdom

Purpose

Refractive treatment options are limited for those with Fuchs endothelial dystrophy (FED) in patients beyond their 5thdecade who seek spectacle independence. Descemet membrane endothelial keratoplasty (DMEK) for corneal decompensation a few years after implantation of multifocal IOLs in eyes with FED has been described. Refractive Lens Exchange (RLE) with trifocal IOL in FED has been described with excellent outcomes. However, modern Extended Depth of Focus (EDOF) IOL provides a continuous, smooth transition from intermediate to distance vision. We present a case report demonstrating the successful integration of RLE with DMEK and Extended Depth of Focus IOL as a novel approach for managing FED.

Setting

Sussex Eye Hospital, University Hospitals Sussex NHS Foundation Trust, Brighton, UK.

 

Report of case

The case involves a 66-year-old patient with high myopia and FED who experienced intolerance to contact lenses and sought spectacle independence for distance and intermediate vision. His corrected distance visual acuity was 20/30 in each eye and was unhappy with the deteriorating quality of vision. Examination revealed FED with no noticeable corneal oedema. In the right and left eye, his central corneal thickness was 506μ and 587μ, and the endothelial cell density (ECD) was 1225 cells/mmand 1399 cells/mm2.He had been for several consultations previously and was deemed ineligible for excimer and femtosecond laser–based refractive surgery due to age and FED. The patient's occupation as a commuter and builder emphasized the need for clear vision without visual disturbances such as glare and halos. The patient underwent a combined phacoemulsification with implantation of a toric EDOF IOL (Vivity, Alcon Laboratories, USA) and 7.75 mm diameter DMEK in both eyes 6 weeks apart. After 12 months, the uncorrected distance visual acuity was 20/16 in each eye, with 20/32 and 20/50 uncorrected near and intermediate visual acuity for 40 to 66 cm from the face in each eye, respectively. The ECD at 12 months was 2050 cells/mm2 and 2100 cells/mmin the right and left eyes, respectively. The patient was pleased with the outcomes.

Conclusion/Take home message

Our findings suggest that the novel approach of combining of RLE with the EDOF lens and DMEK holds great promise in offering better visual outcomes, reduced dependency on visual aids, and enhanced quality of life for FED patients than either DMEK or RLE alone. Despite being a novel approach that remains best suited for refractive surgeons who have vast experience in DMEK procedures, the prospects for visual correction surgery in FED patients appear increasingly promising as developments in surgical techniques and IOL technologies continue to advance.