A Prospective Randomized Control Trial To Measure Posterior Capsular Opacification Rates Following Insertion Of Two Monofocal, Aspheric, Acrylic Intraocular Lenses: The Hydrophobic Rayone 800C And The Hydrophilic Rayone 600C: Twelve-Month Results
Published 2024 - 42nd Congress of the ESCRS
Reference: FP30.09 | Type: Free paper | DOI: 10.82333/kpte-vn80
Authors: Khayam Naderi* 1 , Ashmal Jameel 1 , Sancy Low 1 , Vijay Wagh 1 , Mani Bhogal 1 , Ailsa Ritchie 1 , Scott Robbie 1 , Chris Hammond 1 , Moin Mohamed 1 , Nick Stanojcic 1 , Elodie Azan 1 , Chris Hull 2 , Samantha Mann 1 , David O'Brart 1
1Ophthalmology ,St.Thomas' Hospital,London,United Kingdom, 2Department of Optometry and Visual Science,School of Health and Psychological Sciences, City, University of London,London,United Kingdom
Purpose
Posterior capsular opacification (PCO) is the commonest post-operative complication following cataract surgery and can lead to significant visual morbidity. In this study, we compared PCO rates and visual outcomes following implantation of two monofocal, aspheric, acrylic intraocular lenses (IOL) by the same manufacturer (Rayner Ltd) the hydrophobic RayOne 800C and the hydrophilic RayOne 600C.
Setting
Single-centre, prospective randomised control trial in a university hospital.
Methods
Patients with visually symptomatic cataract(s) were randomised to receive one of the two IOLs during micro-incisional phacoemulsification cataract surgery (CS). Thirty-nine eyes of 39 patients received the RayOne 600C IOL (HPL group) and 46 eyes of 46 patients received the RayOne 800C IOL (HPB group). Patients were seen at baseline and at 4 weeks (4W), 6 months (6M), and 12 months (12M) following CS. Primary outcome measures included the development of visually significant PCO requiring Nd: YAG laser capsulotomy. Secondary outcome measures including visual outcomes (uncorrected distance visual acuity (UDVA) and best-corrected distance visual acuity (BDVA)), patient reported outcome measures (CATPROM-5), and adverse events.
Results
The mean age (years) was 72.46 (+/-standard deviation 7.2) in the HPL group and 68.98 (9.4) in the HPB group (p=0.06). At 4W, there were statistically significant improvements in UDVA, BDVA and CATPROM-5 scores compared to baseline in the HPL group (all p<0.0001), and in the HPB group (all p<0.0001). At 4W, 6M and 12M following CS, there were no statistically significant differences in UDVA, BDVA and CATPROM-5 scores between the HPL group and the HPB group. One patient required Nd: YAG laser capsulotomy for visually significant PCO in the first 12 months following CS in the HPB group, with no cases requiring laser treatment in the HPL group (p=1.00).
Conclusions
Our preliminary results indicate there are no statistically significant differences in post-operative visual outcomes and visually significant PCO between the groups. The trial is ongoing for 24-month follow-up.