Outcomes Of Minor Salivary Gland Transplantation In Severe Dry Eye Disease Secondary To Steven Jhonson Syndrome
Published 2024 - 42nd Congress of the ESCRS
Reference: FP28.06 | Type: Free paper | DOI: 10.82333/h7vt-4r65
Authors: Vishal Kumar* 1 , Namrata Sharma 1 , Prafulla Maharana 1
1OPHTHALMOLOGY,ALL INDIA INSTITUTE OF MEDICAL SCIENCES, NEW DELHI,NEW DELHI,India
Purpose
to present the outcomes of minor salivary gland transplantation in severe dry eyes patients of Steven Johnson syndrome.
Setting
Type of study - Ambispective interventional case series.
Place of Study – Dr R.P Centre for Ophthalmic Sciences, AIIMS, New Delhi
Number of patients- 20 Eyes of 20 patients.
The patients with severe dry eye disease secondary to Steven Johnson syndrome who underwent Minor salivary gland transplantation between 2017 to 2021 with a minimum follow-up of 1 year were included in the study
Methods
Inclusion criteria – patients with SJS having severe dry eyes, and the severe aqueous deficiency (Schirmer score <5 mm). In bilateral patients, the eye with poor visual acuity and poor ocular surface parameters were included. Patients having minimum follow-up 1 year after surgery were included in the study.
Exclusion criteria – any patient having an active infection, corneal ulcer or corneal perforation was excluded from the study.
All the ocular surface parameters were graded according to grading criteria that were developed by Sharma et al. It included Schirmer score, hyperemia score, conjunctivilisation, keratinization, palisades of Vogt, corneal neovascularization, superficial punctate keratitis, and corneal opacity.
Results
The mean age of the patients in the study was 28.6 years (12-70 years). There were 12 female and 8 male patients. There was a significant improvement in mean Postoperative best-corrected visual acuity (BCVA) in 10 (50%) out of 20 patients. The mean preoperative Best corrected Logmar visual acuity was 2.23 which improved postoperatively to 1.93 Logmar at 1 year. Schirmer test scores improved significantly in 15 eyes (75%) 1 year after surgery compared to the baseline value.
There was a significant decrease in corneal opacity score at the 1-year postoperative period.
Neovascularization of the cornea, superficial punctate keratitis and hyperemia decreased significantly at 1 year postoperatively as compared to baseline parameters.
Conclusions
Minor salivary gland transplantation can be offered as an option for severe dry eye secondary to Stevens-Johnson syndrome in improving the ocular surface of these patients.