Ultra High-Resolution Oct In Diagnosing Corneal Epithelial Dystrophies
Published 2024 - 42nd Congress of the ESCRS
Reference: FP15.10 | Type: Free paper | DOI: 10.82333/qe7w-9e61
Authors: Adam Wylegala* 1 , Katarzyna Kryszan 2 , Kamila Rogacz 3 , Katarzyna Bujala 4 , Bogdan Dugiello 5 , Przemysław Wozniak 5 , Dominika Szkodny 5 , Bartłomej Markuszewski 6 , Anna Markuszewska 6 , Edward Wylegala 5
1ophthalmology,Silesian Medical University,Katowice,Poland;ophthalmology,Silesian Medical University,Katowice,Poland, 2ophthalmology,Silesian Medical University,Katowice,Poland, 3Opthalmology,Railway Hospital ,Katowice,Poland, 4ophthalmology,Railway Hospital ,Katowice,Poland, 5Opthalmology,Silesian Medical University,Katowice,Poland, 6Wrocławskie Centrum Okulistyczne,Wrocław,Poland
Purpose
Corneal epithelial dystrophies encompass a spectrum of disorders characterized by abnormal cellular and structural changes in the corneal epithelium, posing challenges to accurate diagnosis and characterization. Optical Coherence Tomography (OCT) has been a valuable imaging modality, providing detailed insights into corneal morphology. However, conventional Optical Coherence Tomography (OCT) may fall short of capturing subtle alterations associated with specific subtypes of corneal dystrophies. This study explores the utility of High-Resolution (HR) OCT in evaluating various subtypes of corneal epithelial dystrophy, focusing on detecting subtle changes not discernible through conventional OCT.
Setting
A prospective, cross-sectional study involving 20 eyes was conducted using the HR Revo OCT (Optopol Technology Zawiercie, Poland). HR Revo is capable of capturing 130k/A scans per second with an axial resolution of 3 µm and a digital resolution of 1.6 µm. Among the eyes examined, 12 exhibited epithelial basement membrane dystrophy, 5 had Meesman dystrophy, and 3 presented with Thygenson dystrophy.
Methods
Measurements were performed using the HR Revo OCT. The study included a diverse sample of 20 eyes with different subtypes of corneal epithelial dystrophy. Specifically, we investigate epithelial basement membrane dystrophy, Meesman, and Thygenson dystrophy using a High-Resolution Revo.The research utilized HR-OCT to capture detailed images and identify nuanced changes in the corneal structure that may go unnoticed with conventional OCT imaging. All participants had an in-vivo corneal confocal microscopy that confirmed the diagnosis.
Results
On HR-OCT imaging, Meesman corneal dystrophy presented with sharply demarcated hyperreflective dots, leaving hypotransmission defects. Conversely, Thygenson dystrophy exhibited flatter, diffusely demarcated, lesions with lower reflectivity, without associated hypotransmission defects. The appearance of Epithelial Basement Membrane Dystrophy (EBMD) varies depending on the type of corneal lesions. Some exhibited hyperreflective lesions while others showed the presence of fine lines spanning through the corneal epithelium
Conclusions
HR-OCT proves to be a valuable tool in diagnosing corneal epithelial dystrophies, surpassing the limitations of conventional OCT. The detailed imaging provided by the HR Revo 130 facilitates the identification of subtle changes in corneal structure, enhancing our ability to differentiate and characterize various subtypes of corneal epithelial dystrophies.
This study emphasizes the potential clinical significance of incorporating HR OCT in the assessment and diagnosis of corneal disorders