Evaluation Of Two Hyaluronic Acid-Containing Artificial Tears In Patients With Dry Eye Disease Following Cataract Surgery: A Randomized Controlled Study
Published 2024 - 42nd Congress of the ESCRS
Reference: FP15.02 | Type: Free paper | DOI: 10.82333/c9d7-tn24
Authors: Chi Chin Sun* 1 , Yuan-Hsi Chan 2 , Pei-Wei Huang 3 , Nan-Ni Chen 4
1School of Medicine, College of Medicine,Chang Gung University,Taoyuan,Taiwan, Province of China;Ophthalmology,Chang-Gung Memorial Hospital,Keelung,Taiwan, Province of China, 2Ophthalmology,Chang-Gung Memorial Hospital,Keelung,Taiwan, Province of China, 3Ophthalmology,Lo-Hsu Medical Foundation, Lotung Poh-Ai Hospital,Yilan,Taiwan, Province of China, 4Ophthalmology,Chang-Gung Memorial Hospital,Chiayi,Taiwan, Province of China
Purpose
To assess the effectiveness of lubricating eye drops that contain either Hydroxypropyl Guar-Hyaluronic Acid (HPG/HA) or Carboxymethylcellulose-Hyaluronic Acid (CMC/HA) in the treatment of Dry Eye Disease (DED) in patients after cataract surgery.
Setting
This was a 3-week, prospective, open-label, assessor-masked, parallel, randomised controlled study conducted between December 2021 and July 2023 at the Department of Ophthalmology, Keelung Chang Gung Memorial Hospital, Taiwan (ClinicalTrials.gov identifier NCT06221345). All patients had post-cataract surgery DED.
Methods
Enrolled patients were randomly assigned in a 1:1 ratio to an HPG/HA or a CMC/HA group 1 week after cataract surgery. Patients received 1-2 drops of HPG/HA or CMC/HA lubricant four times daily for three weeks. The primary endpoint aimed to evaluate the Corneal Fluorescein Staining (CFS) score change at one and three weeks. Secondary endpoints included assessing changes in OSDI score, Schirmer's test score, tear break-up time (TBUT), central corneal sensitivity, and external eye photography at weeks 1 and 3.
Results
70 patients were recruited, with 35 patients in each group. The HPG/HA group demonstrated superior improvements in CFS scores (expressed as means and standard deviations) to the CMC/HA group at week 1 (−1.0 [1.7] vs. −0.1 [1.7], p = 0.039). It demonstrated comparable results at week 3 (−1.6 [1.8] vs. −1.3 [1.9], p = 0.552). No statistically significant differences were observed in other secondary outcomes between groups at weeks 1 and 3 (p > 0.05). Generally, both artificial tears were well tolerated.
Conclusions
HPG/HA and CMC/HA-based lubricant eye drops effectively manage DED in patients after cataract surgery. The HPG/HA group demonstrated superiority by significantly improving CFS scores as early as one week following treatment. Additional studies are necessary to evaluate these findings.