Biomechanical Corneal Effects Of Lasik-Xtra Compared To Conventional Femto-Lasik In High Myopic Eyes
Published 2024
- 42nd Congress of the ESCRS
Reference: FP12.02
| Type: Free paper
| DOI:
10.82333/a4dy-wg79
Authors:
Klemens Paul Kaiser* 1
, Marvin Lucas Biller 1
, Tyll Jandewerth 1
, Petra Davidova 1
, Eva Hemkeppler 1
, Christoph Lwowski 1
, Myriam Böhm 1
, Thomas Kohnen 1
1Department of Ophthalmology,Goethe-University,Frankfurt am Main,Germany
Purpose
This study seeks to investigate the in vivo corneal biomechanical response to femtosecond laser-assisted in situ keratomileusis (FS-LASIK) combined with accelerated corneal crosslinking (LASIK-Xtra) compared to conventional FS-LASIK (convLASIK) in highly myopic eyes.
Setting
Department of Ophthalmology, Goethe-University, Frankfurt, Germany
Methods
In this prospective, randomized fellow eye-controlled clinical trial, we enrolled patients who received treatment with LASIK-Xtra (30mW/cm2, 90 seconds with continuous UVA) in one eye and convLASIK in the fellow eye. Both eyes were subjected preoperatively and twelve months postoperatively to a Corvis ST examination. The stiffness parameter at first applanation (SP-A1), integrated inverse radius (IIR), deformation amplitude (DA), deformation amplitude 2 mm away from apex and the apical deformation (DARatio2mm) were evaluated.
Results
The study included 38 high myopic eyes (-7.34 ± 1.02 diopter) of 19 patients. The results of the corneal biomechanical measurement showed a significant reduction in overall corneal stiffness with a significant decrease in postoperative SP-A1 and increase in IIR, DA, and DARatio2mm (p<.001). In a direct comparison, there was no evidence of an increase in corneal stiffness in the LASIK-Xtra group compared to the convLASIK group twelve months postoperatively. No statistically significant difference was detected in any of the four biomechanical parameters (p>.05).
Conclusions
The corneal biomechanical response to convLASIK and LASIK-Xtra did not vary significantly. With a similar corneal thickness-loss, there was no significant difference in the four biomechanical metrics between the convLASIK and LASIK-Xtra groups. Thus, LASIK-Xtra seems not to have a protective corneal stiffening effect compared to convLASIK twelve months postoperatively.