Shifting Trends In Strain Distribution And Antibiotics Resistance In Bacterial Keratitis: A 26-Year Retrospective Data Analysis
Published 2024 - 42nd Congress of the ESCRS
Reference: FP11.05 | Type: Free paper | DOI: 10.82333/mzyd-dt79
Authors: Chan-Ho Cho* 1 , Sang-Bumm Lee 1
1Ophthalmology,Yeungnam University College of Medicine,Daegu,Korea, Republic Of
Purpose
To analyze changing trends in long-term microbial strain distribution and antibiotic resistance in bacterial keratitis.
Setting
Retrospective, consecutive study. All of study case were taken by Department of Ophthalmology, Yeungnam University College of Medicine, South Korea.
Methods
We conducted an analysis on 542 strains of 462 eyes in which bacteria were detected as a result of infectious keratitis culture at Yeungnam University Hospital over a period of 26 years (1998-2023). The overall results were analyzed by classifying them into Gram-positive (GP) and Gram-negative bacteria (GN). The entire period was divided into the former half (1998-2010, 297 strains) and the latter half (2011-2023, 245 strains) to compare and analyze strain distribution and antibiotic susceptibility.
Results
The most common GP/GN during the entire period were Staphylococcus spp. (177 strains, 33%)/ Pseudomonas spp. (97 strains, 18%). The proportion of GN (51.2% vs. 62.4%, p=0.008), Enterococcus spp. (4.0%:9.4%, p=0.012) and Acinetobacter spp. (1.3%:10.6%, p<0.001) were increased in the latter half. In GP, there was no significant change in MRSA over the period (51.8%:47.5%), and resistance to vancomycin were significantly increased in the latter half (0.7%:8.4%, p=0.007). In GN, resistance to ciprofloxacin (7.5%:14.5%, p=0.078) tended to increase in the latter half. Over the entire period, resistance to carbapenem, ceftazidime, and tobramycin in GN were 6.7%, 8.6%, and 10.9%, respectively, and there was no significant change over the period.
Conclusions
In the strain distribution, an increasing trend was found for GN, Enterococcus spp., and Acinetobacter spp. In terms of antibiotic resistance, an increasing trend was found in resistance to vancomycin in Gram-positive bacteria and to ciprofloxacin in Gram-negative bacteria. Appropriate antibiotic selection is necessary considering the distribution of strains and antibiotic susceptibility trends.