Effect Of Cyclosporine A On Refractive Outcomes And Epithelial Remodelling Post Topography-Guided Lasik
Published 2024 - 42nd Congress of the ESCRS
Reference: FP08.11 | Type: Free paper | DOI: 10.82333/n3ap-kb42
Authors: Tanvi Suhas Haldipurkar* 1
1cataract & refractive,Laxmi Eye Hospital & Institute,Navi Mumbai,India;Cataract,Laxmi Eye Hospital & Institute,Navi mumbai,India
Purpose
To compare the visual acuity, higher order aberrations and epithelial remodeling following topography guided laser in situ keratomileusis (TG-LASIK) with and without postoperative use of topical Cyclosporine 0.05%.
Setting
It was a prospective, observational study conducted over a period of 12 months at a tertiary hospital
Methods
Visual acuity, including uncorrected distance visual acuity (UDVA) and corrected distance visual acuity (CDVA), higher order aberrations- coma, trefoil, spherical and total corneal aberrations and corneal epithelial thickness after topography-guided LASIK were analyzed in 2 groups, Group A- who did not receive 0.05% Cyclosporine and Group B- who received 0.05% Cyclosporine A . Corneal epithelial thickness was mapped across 25 sections and 3 concentric zones using AS-OCT preoperatively and at 1 month, 3 months, and 6 months postoperatively.
Results
Group A had 63 eyes and Group B had 59 eyes. The mean age in group A was 25.8 ± 5.2 years and in group B was 25.7 ± 4.4 years. Both groups showed a progressive increase in epithelial thickness from baseline which was statistically significant. The cetral zone showed a greater increase in thickness in group B which was significant. Rest of the zones showed. variable epithelial pattern which was similar in both groups. The epithelial recovery from baseline to 6 mths was seen to be more uniform in all the zones in group B. The UCDVA was similar in both groups. The visual recovery and gain of lines was seen more in group B. The total HOA were seen to be significantly less in group B. The OSDI score and ID VFQ-33 was better in group B.
Conclusions
Our study shows that epithelial remodelling takes place post TG LASIK in all zones and the use of 0.05% Cyclosporine A results in significant central zone thickening, significant reduction in total higher order aberrations and better visual quality outcomes. The recovery of visual acuity was seen to be faster in group using Cyl A as compared to those who didnt.
Use of cyclosporin A can be considered in patients who need a faster recovery of vision.