A Prospective, Randomized, Contralateral Study Comparing Topography-Guided Lasik To Wavefront-Guided Lasik - One Year Data

To compare outcomes between topography-guided LASIK and wavefront-guided LASIK surgery in the treatment of myopia with and without astigmatism in a prospective, randomized, contralateral eye to eye study. Outcome measures include quality of vision and quality of life metrics using validated questionnaire, high contrast ETDRS visual acuity, low contrast ETDRS visual acuity (5 and 25%), safety, predictability, efficacy and higher order aberration analysis.

Academic refractive surgical service

One hundred eyes of 50 consecutive patients underwent topography-guided LASIK surgery in one eye and wavefront-guided LASIK surgery in their fellow eye. Eyes were randomized according to ocular dominance. The mean pre-operative spherical equivalent refraction was -4.76 +/- 2.09 diopters and -4.65 +/- 2.15 diopters in the wavefront-guided group and topography-guided group respectively (p = 0.80).

At post-operative month twelve, with 80 eyes of 40 patients available for analysis, 100% and 92.5% of eyes had an UDVA of 20/20 or better in the WFG and TG groups, respectively; 78.25% and 68.00% of eyes had an UDVA of 20/16 or better in the WFG and TG groups, respectively; and 20.50% and 22.50% of eyes had an UDVA of 20/12.5 or better in the WFG and TG groups, respectively.  There was no significant difference in the percentage of eyes that gained one or more lines of best corrected distance visual acuity in the WFG (28.25%) and TG (32.50%) groups, respectively (p = 0.81).

Wavefront-guided LASIK and topography-guided LASIK have similar clinical outcomes with excellent safety, efficacy, and predictability in both groups.