Interface Fluid Syndrome 10-20 Years After Uneventful Lasik : 3 Patients, 3 Different Causes

To report a case series of Interface Fluid Syndrome in 3 Patients with a common history of uneventful LASIK 10-20 years ago but with different causes. 

Three patients, 47, 49, and 58 years old, were referred to the cornea clinics of our department complaining about blurry vision in the last months. All three patients had a history of uneventful LASIK in both eyes 10-20 years before presenting. Upon examination, an accumulation of fluid was found in the interface of one eye of each patient, reducing their best-corrected visual acuity. Interestingly, the cause was different in every case, as Fuchs' endothelial dystrophy, primary open-angle glaucoma, and iridocorneal endothelial syndrome were found as causative factors in the 3 cases respectively.  Diagnostic and management modalities of each case were different.

Interface fluid syndrome, although rare in the late postoperative period after LASIK, may appear even decades after uneventful refractive surgery. Prompt diagnosis and identification of the causative factor may improve prognosis modifying treatment accordingly.