ESCRS - P165 - OCULAR SURFACE DISODERS IN PATIENTS WITH TIPE 2 DIABETES MELLITUS

OCULAR SURFACE DISODERS IN PATIENTS WITH TIPE 2 DIABETES MELLITUS

Published 2024 - 28th ESCRS Winter Meeting

Reference: P165 | Type: Presented Poster & Poster | DOI: 10.82333/99xp-p439

Authors: Tetiana Zhmud* 1 , Galyna Drozhzhyna 2

1eye disease,National Pirogov Memorial Medical University, Vinnytsia, Ukraine, ,Vinnytsia,Ukraine, 2cornea,SI “Filatov Institute of Eye Diseases and Tissue Therapy of the NAMS of Ukraine”, Odesa, Ukraine,Odesa,Ukraine

Purpose

We aimed to evaluate expression of neutrophil CD15 and correlate it with results of conjunctival impression cytology and routine objective ocular surface tests (TMH, NIBUT, LLT, MGD) in T2DM patients.

Setting

Diabetes mellitus is associated with increased risk of ocular surface diseases in elderly.
We consider neutrophil CD15 as a potential marker of ocular surface damage in T2DM patients

Methods

We prospectively enrolled sixty T2DM patients (120 eyes) into a study group. The control group included forty (80 eyes) age- and sex-matched almost healthy individuals.
All patients underwent comprehensive ophthalmological examination, namely, tear meniscus height test (TMH), noninvasive tear break-up time (NIBUT), lipid layer thickness (LLT), Meibomian gland dysfunction (MGD), conjunctival impression cytology (CIC) and expression of CD15.

Results

Abnormal Nelson’s grades of squamous metaplasia (grades 2 and 3) were observed in 50% (60 eyes) of the study group, and 13.75% (11 eyes) of the control group. Fifteen patients with T2DM suffered from grade 3 squamous metaplasia. Nelson's grades of squamous metaplasia have shown a positive correlation with the level of CD15 expression either in the study and control groups (rs=0.628, p=˂0.0001; rs=0.746,  p˂0.0001; respectively). In addition, in 15 (12%) cases, cytological examination revealed signs of an inflammatory process in the conjunctiva. These samples contained elements of inflammatory infiltration, mainly in the form of neutrophils, which characterizes an acute process.

Conclusion

The research shows significantly reduced values of routine objective ocular tests in T2DM patients in comparison to healthy participants older than 60 yo. Increased CD15 in the peripheral blood is associated with the development of squamous metaplasia and may be used to evaluate the severity of ocular surface damage in T2DM patients.

Patients with inflammatory infiltration of the bulbar conjunctiva, preparations with hyaluronic acid + low-concentration steroids, in particular hydrocortisone 0.001%, were used.