CORNEAL REGENERATION WITH INTRASTROMAL STEM CELL IMPLANTATION FOR PROGRESSIVE CORNEAL DISEASES
Published 2024 - 28th ESCRS Winter Meeting
Reference: FP19 | Type: Submission | DOI: 10.82333/th7s-mb46
Authors: Ceren Ece Semiz* 1 , Faruk Semiz 1 , Njomza Hıma Musa 1 , Zekerıya Alp Demirsoy 1 , Gamze Tanrıverdi 2 , Gökçe İdil Semiz 3 , Olcay Semiz 1 , Nuray BAŞSÜLLÜ 4 , Merjem Purelku 2
1Ophthalmology,Eye Hospital,Pristina,Kosovo, 2Histology and Embryology,Cerrahpaşa University,İstanbul,Türkiye, 3Medical Faculty,Atılım University,Ankara,Türkiye, 4Pathology,Bakirkoy Dr. Sadi Konuk Training & Research Hospital,İstanbul,Türkiye
Purpose
To investigate the development of new intrastromal histological structures using transmission electron microscopy after fresh myopic human lenticular (FML) implantation with stem cells in advanced keratoconus
Setting
Eye Hospital, Pristina, Kosovo
Methods
Sixty eyes with advanced keratoconus indicated for corneal transplantation were included in this study. FML implants were placed in all eyes through SMILE surgery. Lenticular implants were extracted from patients with myopic refractive errors of the cornea, untreated keratoconus, and treated keratoconus following 1, 2, and 3 years of surgery. These five lenticular samples were examined under the electron microscope and compared.
Results
Healthy keratocytes and telocyte-like cells were observed in samples obtained three years after lenticular implantation. The preoperative CDVA improved from 1.47 ± 0.31 logMAR to 0.48 ± 0.06 logMAR (P < .001). The preoperative CCT increased from 338.35 ± 11.24 µm to 474.35 ± 4.31 µm (P < .001),
Conclusion
Stromal regeneration seems possible in patients with Keratoconus with stem cells and Telocytes.
ClinicalTrials.gov Identifier: NCT04591587