Angioanalysis Of Microvascular Changes Using Oct Angiography In Various Types Of Glaucoma.

Purpose of the study. Detection of early microvascular changes using OCT angiography in various types of glaucoma.

The World Health Organization (WHO) found that worldwide 105 million people suffer from glaucoma and 5 million people are completely blind due to this disease (Quigley H., Broman A.T. The number of people with glaucoma worldwide in 2010 and 2020. Br J Ophthalmol).

Material and methods : The study involved 10 patients (10 eyes) with a diagnosis of primary open-angle glaucoma stage I A (group 1). 10 patients (group 2) 10 people (10 eyes) with a diagnosis of primary angle-closure glaucoma stage I A, aged 40 to 50 (mean age 45.1±3.6) participated. All patients underwent visometry, tonometry, biomicroscopy, gonioscopy, ophthalmoscopy with a Goldmann lens, threshold computed perimetry (with assessment of PSD and MD), as well as examination of the retina on an optical coherence tomograph with angiography function (REVO NX, Optopol, Poland).

Results. In patients with primary open-angle glaucoma stage IA, angio-OCT revealed significant changes in the form of a decrease in blood flow density (vessel density, VD) on the superficial vascular plexus (superficial vascular plexus) 37.16 ± 3.6 , in deep vascular plexus (deep vascular plexus ) 42.95±2.1 of the macular zone than in the second group of patients diagnosed with primary angle-closure glaucoma  on the superficial vascular plexus (superficial vascular plexus) 40.1±2.0, on the deep vascular plexus (deep vascular plexus) 43, 9±1.8 macular area. The decrease in the density of the vascular bed and the blood flow of the peripapillary capillaries of the optic disc in the 1st group was 41.7±1.8, in the second group 42.2±1.4.

Conclusions.

1. Comparative analysis shows that primary open-angle glaucoma stages I A vascular density decreases more than primary angle-closure glaucoma stages I A.
2. Microcirculatory changes in the retina topographically coincide with the corresponding glaucoma defects in the visual fields.