Comparison Between Nepafenac 0.3%, Nepafenac 0.1 % Alone Vs A Combination Of Loteprednol And Nepfenac 0.1% In Controlling Post-Operative Inflammation After Phacoemulsification
Published 2023 - 41st Congress of the ESCRS
Reference: PP16.07 | DOI: 10.82333/8tp2-s373
Authors: Vandhana Sundaram* 1 , Jagadheesh Kumar Reddy 2
1cornea and refractive surgery ,sankara eye hospital ,coimbatore ,India;cornea and refractive surgery ,sankara eye hospital ,coimbatore ,India, 2cornea and refractive surgery ,sankara eye hospital ,coimbatore ,India
To compare the efficacy of nepafenac 0.1% alone vs nepafenac 0.3% and a combination of loteprednol and nepafenac 0.1 % in controlling post-operative inflammation after uneventful phacoemulsification
This prospective study included 750 eyes with senile cataract who underwent uncomplicated phacoemulsification with foldable intraocular lens implantation by a single surgeon.
Pre-operative evaluation included visual acuity assessment, non-contact tonometry, slit lamp evaluation and indirect ophthalmoscopy. First group received Nepafenac 0.3% in tapering doses , second group received Nepafenac 0.1% in tapering doses patients in the topical steroids+Nsaids group received Loteprednol in tapering doses along with Nepafenac 0.1% eye drops. Post operatively patients were reviewed on day 10 and day 45 when visual acuity, conjunctival congestion, cornea and anterior chamber reaction were assessed by two independent observers. Optical coherence tomography of the macula was done on 45th post-operative day to assess macular volume and central macular thickness.
Each group included 250 eyes. There was no statistical significance observed in visual acuity, conjunctival congestion or anterior chamber reaction at day 10 and day 45 between the two groups (p value >0.05). Analysis of OCT macular volume and cystoid macular edema also did not show any statistical significance between the two groups (p value >0.05). 2 patients who received Nepafenac 0.3% had dellen in the post operative follow up hence the drug was discontinued.
No differences were found between Nepafenac 0.3 %, Nepafenac 0.1% and combination of nepafenac 0.1% and steroid group in controlling post-operative inflammation after cataract surgery. Better compliance was also noted in the monotherapy group.