Comparison Aqueous Flare Values In Epidemic Keratoconjunctivitis Patients With Or Without Topical Cyclosporine-A %0.1 Treatment

Adenoviruses are a group of highly contagious viruses and pose a significant public health threat.The most severe type is seen in epidemic keratoconjunctivitis.Subepithelial infiltrates with persistent or recurrent infiltrates may develop as a result of an immune response.Laser flarecell photometry is a noninvasive device that determines the amount of protein in the aqueous humor objectively and quantitatively.Subepithelial infiltrates may show activation from time to time.Cyclosporine reduces risk of recurrence.In this study,we planned to compare the anterior chamber flare measurements of patients with subepithelial infiltrate that we followed up without medication with the help of laser flaremetry and those under cyclosporine treatment.

Beyoglu Eye Trainin and Research Hospital, Istanbul, Turkey

The study included 40 eyes of 40 patients .20 patients were under cyclosporine %0.1 treatment, and 20 patients were being followed up without treatment. 20 healthy volunteers were included in the study as the control group.All patients underwent a full ophthalmologic examination.Patients who had previous ocular surgery,patients using anti-inflammatory drugs and patients with a history of ocular trauma/uveitis were excluded from the study.The laser flare meter (FC-700, Kowa Co. Ltd,Tokyo Japan) was used to measure flare.“Statistical Package for the Social Sciences” version 20 software was used for statistical analysis.Continuous variables were reported as mean, standard deviation, and range

20 patients were under topical cyclosporine %0.1 treatment and 20 patients were being followed up without treatment.Numerous factors can affect aqueous humour flare increase bu we did not find any positive correlation between control group and untreated group. (p:0.233) Also when we compared groupe which under topical cyclosporin group and followed with out treatment; there is no significant aqueous humour flare increase (p:0.12)

Subepithelial infiltrates are caused by the cellular immune response to viral antigens. Deposits are formed in the corneal stroma. Infiltrates may develop weeks, months, or years after the acute phase.The duration and clinical course of the disease depend on the immunity of the individual. In this study there are no evidence of correlation of aqoues humor flare level found between under cyclosporin treatment grope and without treatment.
Further long-term studies are needed to evaluate the effect of flare increase and other causative factors impact on development of subepithelial infiltrates and recurrens.