The Efficacy Of Light-Crosslinking Tissue Adhesive On Histological Corneal And Conjunctiva Wound Healing.
Published 2023 - 41st Congress of the ESCRS
Reference: PP02.08 | DOI: 10.82333/tnws-kq04
Authors: Jo Yeon Ji* 1 , Hui Kyung Kim 2 , Jong Soo Lee 2
1Pusan National University Hospital,Busan,Korea, Republic Of;Medical Research Institute of Pusan National University Hospital,Busan,Korea, Republic Of, 2Pusan National University Hospital,Busan,Korea, Republic Of
To evaluate the newly developed light-crosslinking tissue adhesive (HA glue) on rabbit’s corneal and conjunctival tissue histological recovery after injury.
Randomized control study
Male New Zealand White rabbits (14–16 weeks, 3.0 ± 0.5 kg) of 48 eyes were enrolled. The subjects were divided into three groups; Control, Histoacryl®, and HA glue. The corneal injury was made with a 5-mm full-thickness corneal incision at the upper limbus using a 2.8-mm keratome in 24 eyes. And conjunctival injury was made 5-mm full-thickness conjunctival incision parallel to 2-mm away from the cornea limbus. Histological findings were compared for recovery in the corneal and conjunctival tissues of rabbits on the 7th and 14th days after treatment.
In the control group, inflammatory cell infiltration was evident in the corneal tissue or conjunctival tissue on the after 7th day and 14th day, the inflammatory cell infiltration gradually decreased. Corneal histologic findings, less single-cell inflammatory infiltration was observed in the HA glue group than in the Histoacryl® group. And in conjunctival histologic finding, the HA glue group showed less inflammatory inflammatory infiltration compared to the other groups. The HA glue group showed the best results in recovery of corneal and conjunctival wound tissues compared to other groups.
New light-crosslinking HA glue showed less inflammation infiltration and tissue edema compared to other groups in histological findings. It is thought that the new HA glue has a useful advantage in the recovery of tissue wounds.