Effect Of Mitomycin C On Corneal Endothelium Following Transepithelial Photorefractive Keratectomy After 6 Months

Our aim is investigate the effects of mitomycin-C (MMC) 0.02% on corneal endothelial cell parameters that we use for haze prophylaxis after Transepithelial Photorefractive Keratectomy (TPRK)

Veni Vidi Eye Group

In this retrospective study study ,62 myopic eyes of 31 patients were followed up for 6 months.. We applied 15 seconds MMC % 0.02 to the cornea. Preoperative/surgical parameters and refractive outcomes were documented. Specular microscopy (Nidek, CEM-530) was performed preoperatively and repeated 6 months after surgery to determine changes in cell density (CD), number coefficient of variation (CV), central corneal thickness (CCT), hexagonality (HEX/6A). Haze ratios were also detected in inspections.

 Overall, 42 eyes of 21 participants with mean age of 29.61±5.31 years underwent surgery. Mean preoperative spherical equivalent refractive error was -3.57±1.83 D which was reduced to -0.22±0.30 D postoperatively (P < 0.001). Mean ECD was reduced insignificantly from 2,863±239 cells/mm2  to 2,881±303 cells/mm2  (P = 0.74). Similarly, there was no significant change in CV or Hexagonality at six months (P = 0.91 and 0.52, respectively). Preoperatively residual stromal tissue (RST) was 428±53µm.We found that MMC application had no effect on corneal endothelial cells, regardless of the level of residual stromal tissue (RST). Haze was seen in 2 (%0.03) eyes of the patient only in the 1st month. He was completely healed at 3 months

Application of MMC 0.02% for 15 seconds did not significantly affect corneal endothelial density, coefficient of variation and hexagonality. So it can be used safely and effectively to prevent corneal haze  following TPRK in myopia.