Intrastromal Stem Cell And Telocyt Implantation For Keratoconus
Published 2023 - 41st Congress of the ESCRS
Reference: PO0949 | Type: Free paper | DOI: 10.82333/vjfw-6j42
Authors: Faruk Semiz* 1 , Anita Syla Lokaj 1 , Njomza Hima Musa 1 , Ceren Ece Semiz 1 , Zekeriya Alp Demirsoy 1 , Gokce idil Semiz 2 , Olcay Semiz 1 , Gamze Tanriverdi 3
1Opthtalmology,Eye Hospital,Pristina,Pristina,Kosovo, 2Bahcesehir University,istanbul,Türkiye, 3Cerrahpasa university,istanbul,Türkiye
Purpose
To investigate the development of new intrastromal histological structures using transmission electron microscopy after fresh myopic human lenticular implantation with stem cells and telocytes in advanced keratoconus with the SMILE module.
Setting
EYE HOSPITAL,PRISTINA,KOSOVO
Methods
Sixty eyes with advanced keratoconus with corneal transplantation indication were included in this study. Fresh myopic lenticular implants (FML) were placed in all eyes with SMILE surgery. The patients were followed for 3 years. Three years after implantation, lenticular samples from three patients were examined under the electron microscope and compared.
Results
Demonstrated well-organized parallel lamellar structures. Healthy keratocytes and telocyte-like cells were observed in samples obtained three years after lenticular implantation. Thus, telocyte-like cells may be activated by appropriate stimuli, such as stem cells, and be involved in stromal regeneration. The preoperative CDVA improved from 0.86 ± 0.22 logMAR to 0.47 ± 0.09 logMAR (P < .001). The preoperative CCT increased from 399 ± 13.29 µm to 482.10 ± 8.12 µm (P < .001).
Conclusions
Fresh myopic intrastromal lenticular implantation is a safe, economical, and reliable technique that leads to increased corneal thickness, improved visual acuity, and the regeneration of healthy keratocytes and telocyte-like cells that are involved in stromal regeneration.
NCT04591587