Efficacy And Safety Profile Of Ab-Interno Canaloplasty Performed With And Without Gatt – 12-Month Outcomes

To investigate the clinical outcomes of ab-interno canaloplasty (ABiC) with iTrack microcatheter (Nova Eye Inc) performed as a standalone procedure or combined with gonioscopy-assisted transluminal trabeculotomy (ABiC+GATT) over a 12-month period.

Single center retrospective study

This was a non-randomized, single center, single surgeon, retrospective case series of adult patients with uncontrolled moderate or severe primary open-angle glaucoma and no prior glaucoma surgery, except for SLT or CPC, who were treated with either ABiC or ABiC+GATT. Outcome measures include intraocular pressure (IOP) and number of glaucoma medications.

20 eyes (5 ABiC and 15 ABiC+GATT) of 12 patients (mean age: 71.2±6.6) were included. Mean baseline IOP was 24±5.1 mmHg (ABiC) and 21.6±5.5 mmHg (ABiC+GATT) (p=0.4) and the number of glaucoma medications was 1.4±0.5 (ABiC) and 2.3±0.9 (ABiC+GATT) (p 0.02). At 12 months, mean IOP was reduced to 12.6±1.3 mmHg (ABiC) and 12.9±2.6 mmHg (ABiC+GATT) and the number of medications was reduced to 1±1 and 1.4±0.8 respectively. The IOP reduction was statistically significant (p<0.005) while the reduction in medication was not (p>0.005). There were no significant differences between the two groups postoperatively in IOP (p=0.78) or medications (p=0.41). No adverse events were recorded.

ABiC resulted in a significant reduction in IOP when used as a standalone procedure or in combination with GATT. The postoperative IOP was under control in both groups but the reduction in medications observed was not statistically significant.