Comparison Of The Outcomes Of Mitomycin C Trabeculectomy Vs Igen Implant In Primary Open-Angle Glaucoma Surgery

To compare the outcomes of trabeculectomy with mitomycin C (MMC) versus IgenTM implant in patients with primary open angle glaucoma.

Algiers University of Medecine, Regional Military University Hospital of Blida, Algeria

Patients with moderate to advanced primary open angle glaucoma and uncontrolled intraocular pressure (IOP) on maximally tolerated medical treatment were enrolled. Limbal-based trabeculectomy was performed in all patients by one and the same surgeon. The patients were divided in two groups; the first group had MMC while Igen was used in the second. Outcomes that were analyzed included IOP level before and after surgery, number of glaucoma medications before and after surgery as well as complications. All patients were followed up for at least 3 months.

64 eyes of 53 patients were enrolled in this study, and were divided into 2 groups: MMC group (33 (52%) eyes) and Igen group (31 (48%) eyes). The demographics and preoperative clinical features were not significantly different between the two groups, Repeated measures analysis showed significant decrease in IOP after trabeculectomy in both groups. Over the follow up period, there were no significant changes over time in IOP measurements in both groups.Complications were few and minor in both groups. Bleb revision was needed in three eyes in the MMC group and five eyes in the Igen group. Further glaucoma surgery was needed in five eyes in the first group and two eyes in the second group.

Trabeculectomy with MMC has similar efficacy and safety with Igen. Further studies withlarger number of patients and longer follow up periods are needed.