Tear Biomarker Of Dry Eye Syndrome In Patients With Hashimoto's Thyroiditis
Published 2023 - 41st Congress of the ESCRS
Reference: PO0763 | Type: Free paper | DOI: 10.82333/mq6n-6c91
Authors: Karla Randelovic* 1 , Ivanka Petric Vickovic 1 , Andrea Tesija Kuna 2 , Tomislav Jukic 3 , Zoran Vatavuk 1
1Ophthalmology,UHC Sestre milosrdnice,Zagreb,Croatia, 2Department of Clinical Chemistry,UHC Sestre milosrdnice,Zagreb,Croatia, 3Department for oncology and nuclear medicine,UHC Sestre milosrdnice,Zagreb,Croatia
Purpose
To analyze the tear film of patients with Hashimoto's thyroiditis.
Setting
University Hospital Center Sestre milosrdnice: Ophthalmology department, Department for medical biochemistry, Department for oncology and nuclear medicine. Zagreb, Croatia.
Methods
Two groups were included in this prospective study. The first group of subjects are patients suffering from Hashimoto's thyroiditis in euthyroidism, and the second group is a control group composed of healthy individuals without etiological factors that cause dry eye. Both groups are administered the OSDI questionnaire to assess subjective eye dryness, the precorneal tear film is measured by Pentacam, the thickness of the cornea, the Schirmer test without and with anesthetic, and TBUT. The collected tear sample is analyzed for MMP-9 at the medical biochemistry clinic.
Results
The study included 50 subjects (38.82 ± 10.22 years). The Schirmer I didn't indicate dryness between the two groups of subjects, as well as Schirmer II. TBUT indicated instability of the tear film of patients with HT compared to controls. The thickness of the cornea of the controls is greater, 543.12±25.73 µm, and of HT 552.24±32.38 µm. The precorneal tear film of the HT was thinner. The OSDI score in the HT were from those without dry eye symptoms to those with severe symptoms (11 normal, 6 mild, 1 moderate, 7 severe). Analysis of tear MMP-9 showed that all in the control group had values less than 40 ng/ml, and in the HT group above.
Conclusions
MMP-9 in tears may be a useful and convenient tool to assess and identify inflammation in the eyes of patients with Hashimoto's thyroiditis before the development of more serious dry eye symptoms.