Evaluation Of Corneal Densitometry Changes And Its Correlation With Corneal Keratometric Flattening After Crosslinking In Keratoconus Patients

Published 2023 - 41st Congress of the ESCRS

Reference: PO0613 | DOI: 10.82333/r5zb-2628

Authors: Maria A. Henriquez* ¹ , Claudia Pomatanta ¹ , Rolando Rojas ¹ , Jose Chauca ² , Luis Izquierdo ¹

¹Research Department,Oftalmosalud Institute of Eyes,Lima,Peru, ²Department of Statistics, Demography, Humanities and Social Sciences,Universidad Cayetano Heredia,Lima,Peru

To evaluate corneal densitometry parameters at pre and post corneal crosslinking (CXL) in patients with progressive keratoconus

Research Department at Ofttalmosalud, Instituto de Ojos, Lima, Peru.

Prospective cohort study including 34 eyes of 34 patients evaluated from January 2021 to October 2022 at Oftalmosalud Instituto de Ojos, Lima, Peru. Accelerate epi-off CXL (10 minutes irradiation, ten mW/cm2) was performed using the Avedro System (Massachusetts, USA). Scheimpflug imaging parameters were evaluated preoperatively and at 18 months postoperatively. Corneal densitometry values were assessed at 0-2, 2-6-6-10 mm rings, in the anterior, central and posterior cornea. Statistical analysis was performed using R-program.

Mean corneal total densitometry increase after CXL was 1.69 +/- 1.63 (p= 0.002), mean central densitometry increase at 0-2mm ring and 2-6 mm ring was 2.32+/- 1.53 and 2.59 +/- 1.62 (p = 0.003 both). A significant negative correlation was observed between the total densitometry change and the flattening on the steeper keratometry (K2) (r= -0.50, p= 0.04), and between the central densitometry change at 0-2mm ring and 2-6 mm rings and the flattening on K2 (r=-0.69, p= 0.001 and r= -0.56 p<0.001 respectively) and between the total densitometry change at 2-6 mm ring and the flattening on K2 ( r= -0.70, p <.001).

Conclusion: A significant increase in corneal densitometry occurs after corneal crosslinking, and this increase correlates significantly with keratometric corneal flattening.