ESCRS - PO0554 - Simulation Of Binocular Vision With Extended Depth Of Focus Intraocular Lenses By Image Fusion

Simulation Of Binocular Vision With Extended Depth Of Focus Intraocular Lenses By Image Fusion

Published 2023 - 41st Congress of the ESCRS

Reference: PO0554 | DOI: 10.82333/z6kw-4d26

Authors: Martina Vacalebre* 1 , Luca Vecchiarino 2 , Elena Anastasi 3 , Simon Federico Spanò 3 , Benedetta Castroflorio 3 , Renato Frison 4 , Maria Cristina Curatolo 3

1Department of Mathematical and Computational Sciences, Physics Sciences and Earth Sciences (MIFT), University of Messina,Messina,Italy, 2Ophthalmology Clinic, Department of Medicine and Science of Ageing,University "G. d'Annunzio" Chieti - Pescara,Chieti,Italy, 3Innovation and Medical Science,SIFI SpA,Catania,Italy, 4Optical Consultant SIFI SpA,Catania,Italy

The aim of the study is to evaluate the binocular effect of WELL Fusion (SIFI SpA) system by means of quadratic summation of USAF target images of Mini WELL (SIFI SpA) and Mini WELL PROXA (SIFI SpA), two extended-depth-of-focus intraocular lenses (EDOF IOLs). WELL Fusion involves the bilateral implantation of Mini WELL in the dominant eye and Mini WELL PROXA in the non-dominant eye. This combined binocular system aims to provide uninterrupted good quality of vision at all distances.

Innovation and Medical Science SIFI SpA, Catania, Italy

Mini WELL and Mini WELL PROXA are two non-diffractive aspheric EDOF IOLs with a patented optimized distribution of positive and negative spherical aberrations in the central zone. Mini WELL PROXA was designed to work jointly with Mini WELL and to extend the depth of focus up to 3 D. The OptiSpheric IOL PRO2 was used to perform the United States Air Force (USAF) Target test. The USAF images were taken at the best foci for far, intermediate and near distances at different pupil diameters. A pixel-by-pixel quadratic summation was carried out for each couple of images at the same distance on MATLAB in order to evaluate the binocular effect. The through-focus modulation transfer function (TF-MTF) curves were recorded as reference.

Based on visual evaluation, Mini WELL showed sharper images at far and intermediate distances, whereas the resolution was lower for a near distance equal to 30 cm. At the same time, Mini WELL PROXA showed good resolution at far and intermediate distances, whereas sharper images were obtained both at 45 cm and 30 cm. These results are in accordance with TF-MTF curves, where a proficient synergy between the two IOLs is expected for the near vision. The quadratic summation of each couple of images showed a better image quality than the original single ones. This result further proves the complementarity of Mini WELL and Mini WELL PROXA. The results were confirmed by clinical defocus curves.

The combined binocular EDOF IOL system could provide a wider depth of focus in comparison with a bilateral implantation of the same EDOF IOL. The comparison between simulated retinal images of single EDOF IOLs and the combined system showed a better resolution for the merged images in the WELL Fusion system. Clinical binocular defocus curves of WELL Fusion system confirmed the uninterrupted good quality of vision up to 30 cm, in accordance with the USAF images obtained during the preclinical assessment.