Optical Bench Evaluation Of New Extended Depth Of Focus Intraocular Lenses

The purpose of this study is to evaluate the through focus performance, distance image quality and pupil dependency of three different extended depth of focus (EDF) intraocular lenses (IOLs) using optical bench testing.

Johnson and Johnson Surgical Vision, AMO Groningen B.V., Groningen, The Netherlands and Vision Surgery & Research Centre

Through-focus Modulation Transfer Function (MTF) was measured in a physical eye model with the average chromatic and spherical aberration of the cornea in white light for different pupil sizes. Distance image quality was determined using the MTF at 50 c/mm and simulated visual acuity (sVA) was calculated using the area under the MTF up to 50 c/mm as described in previous publications. Three EDF IOLs were included in the study: a refractive EDF IOL based on a continuous change in power (DEN00V), a refractive EDF based on a combination of 4th and 6th order spherical aberration in the central part of the lens (Ysmart) and the EDF IOL model DFT015.

Model DEN00V showed the best distance image quality for photopic (3mm) and mesopic (4 and 5mm) pupils. Its MTF was 20% and 36 % higher than that of model DFT015 for 3 and 5mm respectively and 35% and 53% higher than that of model Ysmart. Additionally, model DEN00V provided similar intermediate sVA than model DFT015 for all pupil sizes and better near sVA for photopic pupils (2 and 3mm). The relative performance of the Ysmart IOL was strongly pupil dependent with a myopic best focus shift of around -0.75D for 2mm pupil. For a standard photopic pupil of 3 mm, Ysmart provided similar intermediate sVA and worse near sVA than the other two IOLs.

Conclusions:

Optical bench testing shows that the new refractive EDF IOL, model DEN00V, provides higher distance image quality for photopic and mesopic pupils than the other two EDF IOLs included in this study. Although simulated intermediate sVA was comparable for the three IOLs for most of the pupil sizes, the relative near performance depends on the pupil size. For photopic pupils, model DEN00V proves superior near sVA than the other EDF IOLs.