Comparison Of Quality Of Vision Between Two New Extended Depth-Of-Focus Intraocular Lenses: Isopure® Versus Vivity®

To assess differences in photopic and mesopic contrast sensitivity, mesopic visual acuity, and photic phenomena after same-day bilateral cataract surgery with implantation of Isopure^® or Vivity^®, with mini-monovision.

Vista Alpina Eye Clinic, Visp, Switzerland

This is a single-centre, double-blind, randomised, prospective study of 136 operated eyes of 68 patients, implanted bilaterally with Isopure^® or Vivity^®, two new non-diffractive presbyopia-correcting IOL. Mini-monovision (-0.5D) was used in all patients. Mesopic binocular uncorrected distance visual acuity (UDVA), contrast sensitivity in photopic and mesopic conditions (CSV-1000 test, Vector Vision) and subjective ratings of picture-referenced photic phenomena are assessed four to six months after surgery. Patient enrolment is complete (68 patients, 136 eyes).

The current pre-programmed interim analysis is based on 4-to-6-month data from 31 patients, 62 eyes.
Mesopic binocular uncorrected distance visual acuity (UDVA) was +0.14±0.09D and +0.25±0.13D for Isopure^® and Vivity^®, respectively (p = 0.01).
Contrast sensitivity scores at a spatial frequency of 6 cycles per degree were slightly better in patients implanted with Isopure^®: 1.94 log vs. 1.84 log under photopic, 1.58 log vs. 1.44 log under mesopic conditions, for Isopure^® and Vivity^® respectively. Overall, 84%, 90% and 84% of patients reported only very mild or no symptoms at all of glare, halos and starburst, respectively, with no significant differences between the two study groups.

According to this interim analysis, mesopic binocular UDVA and photopic as well as mesopic contrast vision are better with Isopure^®. The rate of patient-reported photic phenomena was low and comparable between the two lenses.
The study is nearing completion and the final analysis will be presented at the ESCRS Congress in Amsterdam.