Evaluation Of Fungal Keratitis By Anterior Segment Optical Coherence Tomography

To evaluate the role of anterior segment optical coherence tomography in follow up of fungal keratitis and response to treatment

Ophthalmology department-Faculty of Medicine- Minia University-Minia -Egypt

Prospective, consecutive clinical series of cases. 23 eyes of 23 patients with proven fungal keratitis clinically were included in the study.

The patients received medical treatment. Slit lamp examination and photography and anterior segment optical coherence tomography was performed at initial and follow up visits weekly till corneal healing occurs. The main outcomes measures included: Infiltrate depth, width, and density, Central corneal thickness (CCT), Minimal corneal thickness (MCT), Corneal thickness at the site of the lesion (CTL),  stromal and Corneal epithelial thickness at the center of the lesion (STL) and (CETL), respectively

23eyes of 23 patients (17 males, 6 females), mean age 42.5 ± 19 (8-66 years), Localization of lesion was central in 14 cases, paracentral/peripheral in 9 cases. Healing time was 6-12 weeks.

Minimal corneal thickness (MCT), corneal thickness at site of lesion (CTL), and stromal thickness at center of lesion (STL), and also infiltrate width and depth changed significantly from 1^st visit to healing stage at last follow up (0.009, 0.001,0.007,0.001 and ˂0.001 respectively).

AS-OCT can provide the clinician with a quantitative assessment of a number of corneal parameters in fungal keratitis that can be used to gauge therapy effectiveness and confirm complete healing of the lesions that can’t be achieved by clinical evaluation.