Visual Performance And Patient Reported Visual Disturbances With Two Presbyopia-Correcting Intraocular Lenses: A Randomized Bilateral Study

Purpose: To assess patient reported visual performance, visual disturbances, and patient satisfaction with trifocal intraocular lens (IOL; AcrySof IQ PanOptix) and an extended Depth of Focus (EDOF)/bifocal IOL (TECNIS Synergy).

A prospective, multicenter, randomized, double-masked, bilateral study conducted in patients (aged >22 years) presenting for routine cataract surgery in five centers throughout the United States.

A prospective, multicenter, randomized, double-masked, bilateral study conducted in patients (aged >22 years) presenting for routine cataract surgery and having a projected uncorrected visual acuity better than 0.10 logMAR postoperatively. Patients were randomized (1:1) to either PanOptix (P) or Synergy (S) IOL bilateral implantation. The interim study-wide data are reported at 6 months postoperatively(P, n=84; S, n=81) for binocular uncorrected visual acuity(UCVA, logMAR), patient reported visual disturbances, spectacle independence, and visual satisfaction using validatedquestionnaires (Questionnaire for Visual Disturbances [QUVID]; Intraocular Lens Satisfaction [IOLSAT]).

Interim at 6 month, photopic binocular UCVA at 4 M, 60, 40, and 33 cm was: (P) 0.03±0.08, 0.09 ± 0.14, 0.14 ± 0.13, and 0.22 ± 0.12; (S) 0.05 ± 0.09, 0.09 ± 0.13, 0.12 ± 0.11, and 0.21 ± 0.11, respectively. Patients (P vs S) experiencing starbursts: 54.9% vs 75.0%; halos: 53.7% vs 58.4%; glare: 34.2% vs 56.6%. Of patients reporting visual disturbances, those who had not experienced/not at all bothered vs quite a bit–very much bothered by starbursts: (P) 57.3% vs 11.0%, (S) 32.9% vs 23.7%; halos: (P) 59.8% vs 7.3%, (S) 53.2% vs 9.1%; glare: (P) 67.1% vs 7.3%, (S) 48.7% vs 10.5%. Patients who reported satisfied-very satisfied with their vision: P 80.7% and 77.3%. Patients who would choose the same lens again were 86.9% (P) and 72.8% (S).

These interim data suggest that PanOptix providesimilar range of vision as Synergy for binocular visual acuity at all distances, including near at 33 cm The data also suggests thatmore PanOptix patients trended less visual disturbances than Synergy patients at 6 months. Majority of patients in both groups were satisfied with their vision at 6 months.