Allogenic Corneal Lenticule For Presbyopia Treatment: Four-Year Visual And Topographic Outcomes

Published 2023 - 41st Congress of the ESCRS

Reference: FP27.09 | Type: Free paper | DOI: 10.82333/cvjt-sj04

Authors: Zeki Yiğit Karaca* ¹ , Fatma Feyza Nur Keskin Perk ¹ , Cafer Tanrıverdi ¹ , Aylin Kılıç ¹

¹Ophthalmology,Medipol University,Istanbul,Türkiye

Purpose

To assess 4-year visual acuity results of allogenic presbyopic lenticule designed to improve intermediate and near vision by modifying the anterior surface shape of the central cornea.

Setting

Istanbul Medipol University Hospital, Ophthalmology Department, Istanbul, Turkey

Methods

30 eyes were treated at our clinic during the EU multi-center clinical trial. All patients were emmetropic patients with presbyopia who needed a reading addition of between 1.50 and 2.50 diopters(D) and had a near vision(33 cm) at or below 0.5 without correction. They underwent the implantation of allogenic corneal lenticule (Allotex) in the non-dominant eye. Binocular as well as treated and untreated uncorrected distance(UCDVA), intermediate(70 cm)(UCIVA) and near vision(40 cm)(UCNVA) were assessed preoperatively and after 4 years. Best-corrected distance visual acuity(BCDVA) was evaluated for safety, A paired t-test was applied to compare pre-operative and postoperative means.

Results

One eye was lost in follow-up.

Binocular UCDVA remained unchanged(p=0.36).Binocular UCIVA and UCNVA were significantly increased from 0.83±0.18 to 0.98±0.07(p<0.01) and 0.41±0.15 to 0.90±0.17(p<0.01).

For the treated eye,UCDVA decreased from 0.97±0.08 to 0.83±0.20(p=0.04).UCIVA and UCNVA were significantly increased from 0.67±0.17 to 0.94±0.12(p<0.01) and 0.37±0.21 to 0.82±0.22 (p<0.01).

For the untreated eye,UCDVA decreased from 0.99±0.05 to 0.93±0.13(p=0.045).UCIVA and UCNVA decreased from 0.67±0.21 to 0.51±0.26(p=0.01) and 0.34±0.15 to 0.26±0.14(p=0.001).

BCDVA of treated eye was decreased from 0.97±0.08 to 0.95±0.10(p=0.011).BCDVA change of the untreated eye was not statistically significant.None of the eyes lost more than 2 lines of BCDVA.

Conclusions

Allogenic corneal lenticule treatment is a way to improve intermediate and near visual acuity with excellent binocular vision at all distances even 4 years after implantation. Even the untreated eye continued to decrease intermediate and near vision.

The minor distance vision loss in the patient's non-dominant eye is not influencing the binocular vision due to summation. No late onset of corneal haze was found as reported with synthetic corneal inlays.