7Mm Frozen And Dried-Preserved 50Um Amnion Disc (Ad) In Wound Healing Following Minimal-Epithelial Removal Photorefractive Keratectomy (Mini-Prk)-A Contralateral Eye Study.
Published 2023 - 41st Congress of the ESCRS
Reference: FP11.09 | Type: Free paper | DOI: 10.82333/73cj-gb32
Authors: Anastasios John John Kanellopoulos* 1 , Alexandros John Kanellopoulos 2
1Ophthalmology,LaserVision Ambulatory Eye Surgery Unit,Athens,Greece;Ophthalmology,NYU Med School,New York,United States, 2Ophthalmology,LaserVision Ambulatory Eye Surgery Unit,Athens,Greece
Purpose
Compare the safety and efficacy of using a 7mm disc of 50um amnion in myopic mini-PRK
Setting
Laservision Ambulatory Surgical Center, Athens, Greece.
Methods
30 Patients that underwent myopic mini-PRK had one eye randomized to receive prior to the bandage contact lens placement an epithelial-side up 7mm in diameter 50um in thickness amnion disc that was applied dehydrated on the exposed stromal surface, attached by natural hydration. Both eyes were evaluated daily up to complete re-epithelization, at month 1 and month 3 post-PRK by slit lamp biomicrocopy & fluorescein staining, refractive data as well as subjective first night discomfort experienced by each patient, in each eye on a scale 0-4 (0=no discomfort, 4=severe discomfort).
Results
Full-re-epithelization: 25 eyes with adjunct Ad by day 3 vs. 9 contralateral eyes. All eyes re-epithelialized by day 4. There were no differences in UDVA, CDVA and residual refractive error between the 2 groups. There was statistical difference in epithelial mapping at 1 month only between the Ad group and the non Ad group, with the former demonstrating smoother epithelial remodeling. Ad first night pain score 0.5, non-Ad: 1.2 ( statistically significant)
Conclusions
Thin amnion disc used as an adjunct bandage in PRK may accelerate re-epithelization, improve first day pain profile and also improve epithelial remodeling within the first postoperative month.