Effect Of Violet Light Filtration And High-Resolution Lathing On Clinical Performance And Patient Satisfaction With The Tecnis Symfony Optiblue Edof Iol

Prior retrospective review demonstrated significant reduction in dysphotopsia complaints and counseling required for dysphotopsia symptoms in patients with Tecnis Symfony Optiblue IOL (models ZXR00V and ZXW150) with violet light filter and high-resolution lathing compared to Tecnis Symfony IOL (models ZXR00 and ZXT150). This prospective study evaluates visual performance, patient-reported dysphotopsia profile, patient satisfaction, and clinic chair time.

Single-center in Bakersfield, CA, USA

This is a randomized, prospective, single-center, bilateral, subject/evaluator masked clinical trial with followup at 1 and 6 months. A total of 60 adults with cataracts and <1.0 D of predicted post-operative corneal astigmatism were randomized and bilaterally implanted with model ZXR00V/ZXW150 or model ZXR00/ZXT150 IOLs, targeting emmetropia in all eyes. Key endpoints included patient reported dysphotopsia (glare, halos, and starbursts) symptoms, low contrast visual acuity with and without glare, and patient satisfaction. Other endpoints include visual acuity, manifest refraction, near point of defocus, preferred reading distance, and clinic chair time.

At 1 month, of patients reporting any symptoms, significantly fewer with ZXR00V/ZXW150 than with ZXR00/ZXT150 had “a lot of difficulty with, or do not do” activities due to halos (p=0.016) or starbursts (p=0.028). Although trending in favor of ZXR00V/ZXW150, there were no significant differences in mean 10% and 25% photopic (p=0.17 / p=0.96) or mesopic (p=0.07 / p=0.50) low contrast visual acuity or 25% mesopic low contrast visual acuity with glare (p=0.39). 100% of ZXR00V/ZXW patients were “overall happy with…vision,” “would recommend this lens to…friends/family,” and “would…do this again.” No significant differences in visual acuity, manifest refraction, near point of defocus, preferred reading distance, and clinic chair time were noted.

The addition of a violet light filter and high-resolution lathing to the Tecnis Symfony Optiblue IOL (ZXR00V/ZXW150) provided significant improvements in the patient-reported outcome measures of halos and starbursts when compared to the Tecnis Symfony IOL (ZXR00/ZXT150). Patient satisfaction measures also trended in favor of the Tecnis Symfony Optiblue IOL. Clinical performance was otherwise similar between the two IOLs.